PMID- 26632990
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20181113
IS  - 1740-634X (Electronic)
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 41
IP  - 7
DP  - 2016 Jun
TI  - Dynamic Resting-State Functional Connectivity in Major Depression.
PG  - 1822-30
LID - 10.1038/npp.2015.352 [doi]
AB  - Major depressive disorder (MDD) is characterized by abnormal resting-state 
      functional connectivity (RSFC), especially in medial prefrontal cortical (MPFC) 
      regions of the default network. However, prior research in MDD has not examined 
      dynamic changes in functional connectivity as networks form, interact, and 
      dissolve over time. We compared unmedicated individuals with MDD (n=100) to 
      control participants (n=109) on dynamic RSFC (operationalized as SD in RSFC over 
      a series of sliding windows) of an MPFC seed region during a resting-state 
      functional magnetic resonance imaging scan. Among participants with MDD, we also 
      investigated the relationship between symptom severity and RSFC. Secondary 
      analyses probed the association between dynamic RSFC and rumination. Results 
      showed that individuals with MDD were characterized by decreased dynamic (less 
      variable) RSFC between MPFC and regions of parahippocampal gyrus within the 
      default network, a pattern related to sustained positive connectivity between 
      these regions across sliding windows. In contrast, the MDD group exhibited 
      increased dynamic (more variable) RSFC between MPFC and regions of insula, and 
      higher severity of depression was related to increased dynamic RSFC between MPFC 
      and dorsolateral prefrontal cortex. These patterns of highly variable RSFC were 
      related to greater frequency of strong positive and negative correlations in 
      activity across sliding windows. Secondary analyses indicated that increased 
      dynamic RSFC between MPFC and insula was related to higher levels of recent 
      rumination. These findings provide initial evidence that depression, and 
      ruminative thinking in depression, are related to abnormal patterns of 
      fluctuating communication among brain systems involved in regulating attention 
      and self-referential thinking.
FAU - Kaiser, Roselinde H
AU  - Kaiser RH
AD  - Department of Psychiatry, Harvard Medical School, and Center for Depression, 
      Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA.
FAU - Whitfield-Gabrieli, Susan
AU  - Whitfield-Gabrieli S
AD  - Department of Brain and Cognitive Sciences, Massachusetts Institute of 
      Technology, Cambridge, MA, USA.
FAU - Dillon, Daniel G
AU  - Dillon DG
AD  - Department of Psychiatry, Harvard Medical School, and Center for Depression, 
      Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA.
FAU - Goer, Franziska
AU  - Goer F
AUID- ORCID: 0000-0002-4641-9945
AD  - Department of Psychiatry, Harvard Medical School, and Center for Depression, 
      Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA.
FAU - Beltzer, Miranda
AU  - Beltzer M
AD  - Department of Psychiatry, Harvard Medical School, and Center for Depression, 
      Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA.
FAU - Minkel, Jared
AU  - Minkel J
AD  - Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 
      Durham, NC, USA.
AD  - Department of Psychiatry, University of North Carolina at Chapel Hill School of 
      Medicine, Chapel Hill, NC, USA.
FAU - Smoski, Moria
AU  - Smoski M
AD  - Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 
      Durham, NC, USA.
FAU - Dichter, Gabriel
AU  - Dichter G
AD  - Department of Psychiatry, University of North Carolina at Chapel Hill School of 
      Medicine, Chapel Hill, NC, USA.
FAU - Pizzagalli, Diego A
AU  - Pizzagalli DA
AD  - Department of Psychiatry, Harvard Medical School, and Center for Depression, 
      Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA.
LA  - eng
GR  - R01 MH101521/MH/NIMH NIH HHS/United States
GR  - R00 MH094438/MH/NIMH NIH HHS/United States
GR  - R01 MH068376/MH/NIMH NIH HHS/United States
GR  - R01 MH095809/MH/NIMH NIH HHS/United States
GR  - U54 HD079124/HD/NICHD NIH HHS/United States
GR  - F32 MH106262/MH/NIMH NIH HHS/United States
GR  - R21 MH094781/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151203
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Depressive Disorder, Major/*diagnostic imaging/*pathology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/*diagnostic imaging
MH  - *Nonlinear Dynamics
MH  - Oxygen/blood
MH  - Prefrontal Cortex/diagnostic imaging
MH  - Psychiatric Status Rating Scales
MH  - *Rest
MH  - Young Adult
PMC - PMC4869051
EDAT- 2015/12/04 06:00
MHDA- 2018/01/03 06:00
PMCR- 2017/06/01
CRDT- 2015/12/04 06:00
PHST- 2015/10/13 00:00 [received]
PHST- 2015/11/20 00:00 [revised]
PHST- 2015/11/30 00:00 [accepted]
PHST- 2015/12/04 06:00 [entrez]
PHST- 2015/12/04 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - npp2015352 [pii]
AID - 10.1038/npp.2015.352 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2016 Jun;41(7):1822-30. doi: 10.1038/npp.2015.352. Epub 
      2015 Dec 3.