PMID- 26633704 OWN - NLM STAT- MEDLINE DCOM- 20160627 LR - 20220330 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 10 IP - 12 DP - 2015 TI - What Are the Major Determinants in the Success of Smoking Cessation: Results from the Health Examinees Study. PG - e0143303 LID - 10.1371/journal.pone.0143303 [doi] LID - e0143303 AB - Understanding mechanisms underlying smoking-related factors should be prioritized in establishing smoking prevention and cessation policy. The aim of this study was to identify factors significantly associated with smoking initiation and/or smoking cessation as well as the most important determinants of successful smoking cessation in a developed non-Western setting. Based on multiple logistic regression models, the odds ratios (ORs) for smoking initiation and cessation were estimated among males (N = 24,490) who had participated in the Health Examinees (HEXA) study. The Cox proportional hazards regression model was used to assess the association between selected predictors of smoking cessation and the likelihood of reaching this goal. Finally, Kaplan-Meier curves were constructed to illustrate the distribution of time from age at smoking initiation to age at smoking cessation. We found that the ORs for successfully quitting smoking increased with age, married status, educational achievement, having a non-manual job, drinking cessation and disease morbidity. Those exposed to secondhand smoking showed less likelihood of quitting smoking. A continual decrease in the ORs for successfully quitting smoking was observed according to increased smoking duration, smoking dose per day and lifetime tobacco exposure (ptrend <0.001). Among the selected predictors, lifetime tobacco exposure, educational attainment, alcohol drinking status and birth cohort were the major determinants in the success of smoking cessation. Our findings suggest that lifetime tobacco exposure, educational attainment, alcohol drinking status and birth cohort can determine success in smoking cessation. Public interventions promoting a smoke-free environment are needed to reinforce discouraging the initiation of, reducing, and quitting cigarette smoking. FAU - Yang, Jae Jeong AU - Yang JJ AD - Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. AD - Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea. FAU - Song, Minkyo AU - Song M AD - Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. AD - Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea. AD - Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea. FAU - Yoon, Hyung-Suk AU - Yoon HS AD - Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. AD - Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea. AD - Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea. FAU - Lee, Hwi-Won AU - Lee HW AD - Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. AD - Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea. FAU - Lee, Yunhee AU - Lee Y AD - Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. AD - Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea. FAU - Lee, Sang-Ah AU - Lee SA AD - Department of Preventive Medicine, Kangwon National University, Kangwon-do, Korea. FAU - Choi, Ji-Yeob AU - Choi JY AD - Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. AD - Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea. AD - Cancer Research Institute, Seoul National University, Seoul, Korea. FAU - Lee, Jong-Koo AU - Lee JK AD - JW Lee Center for Global Medicine, Seoul National University College of Medicine, Seoul, Korea. AD - Department of Family Medicine, Seoul National University College of Medicine, Seoul, Korea. FAU - Kang, Daehee AU - Kang D AD - Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. AD - Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea. AD - Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea. AD - Cancer Research Institute, Seoul National University, Seoul, Korea. LA - eng PT - Journal Article DEP - 20151203 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Tobacco Smoke Pollution) SB - IM MH - *Achievement MH - Adult MH - Aged MH - Alcohol Drinking/psychology MH - Educational Status MH - Female MH - Humans MH - Male MH - Middle Aged MH - Models, Theoretical MH - *Motivation MH - Smoking Cessation/*psychology MH - Tobacco Smoke Pollution PMC - PMC4669113 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2015/12/04 06:00 MHDA- 2016/06/28 06:00 PMCR- 2015/12/03 CRDT- 2015/12/04 06:00 PHST- 2015/06/22 00:00 [received] PHST- 2015/11/02 00:00 [accepted] PHST- 2015/12/04 06:00 [entrez] PHST- 2015/12/04 06:00 [pubmed] PHST- 2016/06/28 06:00 [medline] PHST- 2015/12/03 00:00 [pmc-release] AID - PONE-D-15-27272 [pii] AID - 10.1371/journal.pone.0143303 [doi] PST - epublish SO - PLoS One. 2015 Dec 3;10(12):e0143303. doi: 10.1371/journal.pone.0143303. eCollection 2015.