PMID- 26634548
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20161126
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 4
DP  - 2015 Dec 2
TI  - Polymorphisms in CYP17, COMT, and ESR1 genes in women after menopause and 
      association with bone mineral density.
PG  - 15802-10
LID - 10.4238/2015.December.1.32 [doi]
AB  - In this study, we evaluated genetic factors related to the mineral density during 
      post-menopause. We evaluated 110 women in the first 5 years post-menopause, 
      without previous hormone replacement therapy. Cytochrome P450 17 (CYP17) 
      (rs743572), catechol-O-methyl transferase (COMT) (rs4680), and estrogen receptor 
      1 (ESR1) (rs9322331) were examined for the presence of polymorphisms. Clinical 
      data were collected by anamnesis; all patients had the osseous densitometry 
      examined using a lunar instrument to determine mineral osseous densitometry in 
      the lumbar column (L2-L4). CYP17, COMT, and ESR1 genotyping was carried out by 
      polymerase chain reaction with DNA collected from buccal swabs. The average age 
      was 51.96 years. The average weights of the patients in control and osteopenia 
      groups were 70.25 +/- 12.00 and 62.45 +/- 11.64, respectively (P = 0.001) and body 
      mass index (P = 0.006; control: 29.43 +/- 5.25; osteopenia: 26.72 +/- 4.57). Related 
      to CYP17 polymorphisms, 28.18% of women were TT (wild-type homozygous), 60% were 
      TC (heterozygous), and 11.82% were CC (mutated homozygous). Related to COMT 
      polymorphisms, 53.64% of women were GG (wild-type homozygous), 37.27% were GA 
      (heterozygous), and 9.09% were AA (mutated homozygous). Related to ESR1, 53.64% 
      of women were CC (wild-type homozygous), 40.91% were CT (heterozygous), and 5.45% 
      were TT (mutated homozygous). The ESR1 variant allele was significantly higher in 
      the osteopenia group when compared with women in the normal group (P = 0.02). 
      ESR1 may be associated with low mineral osseous densitometry, while CYP17 and 
      COMT gene polymorphisms were not associated with mineral osseous densitometry.
FAU - Goncalves, C G
AU  - Goncalves CG
AD  - Laboratorio de Ginecologia Molecular e Proteomica, Departamento de Ginecologia, 
      Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil.
FAU - Almeida, B C
AU  - Almeida BC
AD  - Laboratorio de Ginecologia Molecular e Proteomica, Departamento de Ginecologia, 
      Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil.
FAU - Camargo-Kosugi, C M
AU  - Camargo-Kosugi CM
AD  - Laboratorio de Ginecologia Molecular e Proteomica, Departamento de Ginecologia, 
      Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil cintiakosugi@gmail.com.
FAU - Costa, A M M
AU  - Costa AM
AD  - Laboratorio de Ginecologia Molecular e Proteomica, Departamento de Ginecologia, 
      Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil.
FAU - Silva, I D C G
AU  - Silva ID
AD  - Laboratorio de Ginecologia Molecular e Proteomica, Departamento de Ginecologia, 
      Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil.
FAU - Haidar, M A
AU  - Haidar MA
AD  - Laboratorio de Ginecologia Molecular e Proteomica, Departamento de Ginecologia, 
      Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil.
LA  - eng
PT  - Journal Article
DEP - 20151202
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Estrogen Receptor alpha)
RN  - EC 1.14.14.19 (Steroid 17-alpha-Hydroxylase)
RN  - EC 2.1.1.6 (COMT protein, human)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Bone Density/*genetics
MH  - Bone Diseases, Metabolic/etiology/pathology
MH  - Catechol O-Methyltransferase/*genetics
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - *Genetic Association Studies
MH  - Genotype
MH  - Humans
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - *Postmenopause
MH  - Risk Factors
MH  - Steroid 17-alpha-Hydroxylase/*genetics
EDAT- 2015/12/05 06:00
MHDA- 2016/09/16 06:00
CRDT- 2015/12/05 06:00
PHST- 2015/12/05 06:00 [entrez]
PHST- 2015/12/05 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
AID - gmr6456 [pii]
AID - 10.4238/2015.December.1.32 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Dec 2;14(4):15802-10. doi: 10.4238/2015.December.1.32.