PMID- 26634551
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20151204
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 4
DP  - 2015 Dec 3
TI  - Relationship between the HLA-G 14 bp insertion/deletion polymorphism and 
      susceptibility to autoimmune disease: a meta-analysis.
PG  - 15839-47
LID - 10.4238/2015.December.1.35 [doi]
AB  - Numerous studies have investigated the potential relationship between the human 
      leukocyte antigen (HLA)-G 14-bp insertion/deletion (INS/DEL) polymorphisms and 
      autoimmune disease (AID). However, published results are inconclusive. Our aim 
      was to determine whether the 14-bp INS/DEL polymorphism in the HLA-G gene 
      contributes to the risk of AID. A systemic literature search of the PubMed and 
      EMBASE databases was conducted to identify eligible studies investigating the 
      association of the HLA-G 14-bp INS/DEL polymorphism with AID. Our analysis 
      included 11 publications involving a total of 6462 individuals. Overall, no 
      significant association between the HLA-G 14-bp INS/DEL polymorphism and AID was 
      detected in any comparison model. Further subgroup analyses based on AID types 
      and ethnicity also revealed no significant associations. Our results suggest that 
      the HLA-G 14-bp INS/DEL polymorphism is unrelated to the development of AID. 
      Further studies including larger sample sizes are warranted to confirm these 
      results.
FAU - Kim, S K
AU  - Kim SK
AD  - Kohwang Medical Research Institute and Department of Pharmacology, College of 
      Medicine, Kyung Hee University, Seoul, Korea.
FAU - Jeong, K H
AU  - Jeong KH
AD  - Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Kang, I J
AU  - Kang IJ
AD  - Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Chung, J H
AU  - Chung JH
AD  - Kohwang Medical Research Institute and Department of Pharmacology, College of 
      Medicine, Kyung Hee University, Seoul, Korea.
FAU - Shin, M K
AU  - Shin MK
AD  - Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Lee, M H
AU  - Lee MH
AD  - Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, 
      Korea mhlee@khmc.or.kr.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20151203
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Autoimmune Diseases/diagnosis/*genetics/immunology
MH  - Case-Control Studies
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA-G Antigens/*genetics
MH  - Humans
MH  - *INDEL Mutation
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
EDAT- 2015/12/05 06:00
MHDA- 2016/09/16 06:00
CRDT- 2015/12/05 06:00
PHST- 2015/12/05 06:00 [entrez]
PHST- 2015/12/05 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
AID - gmr6552 [pii]
AID - 10.4238/2015.December.1.35 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Dec 3;14(4):15839-47. doi: 10.4238/2015.December.1.35.