PMID- 26634553
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20161230
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 4
DP  - 2015 Dec 3
TI  - Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis.
PG  - 15859-68
LID - 10.4238/2015.December.1.37 [doi]
AB  - Although a number of studies have reported that human leukocyte antigen 
      (HLA)-DRB1 alleles may be correlated with tuberculosis (TB), most were based on 
      small samples or inconsistent and unclear results. Here, we present a 
      meta-analysis to investigate the relationship between HLA-DRB1 alleles and TB 
      susceptibility. We gathered relevant information from published studies on the 
      association between HLA‑DRB1 alleles and TB susceptibility through a systematic 
      research. Data from eligible fifteen studies were included in the meta-analyses. 
      Each dataset was statistically analyzed to evaluate the HLA‑DRB1 alleles by 
      calculating the respective odds ratios (ORs) and 95% confidence intervals (CIs). 
      The results revealed that frequencies of two DRB1 alleles were significantly 
      decreased in TB: DRB1*03 (P = 0.016, OR = 0.78, 95%CI = 0.67‑0.95) and DRB1*07 (P 
      = 0.017, OR = 0.81, 95%CI = 0.68‑0.96). Thus, our data indicate that DRB1*03 and 
      DRB1*07 may provide protective effects against TB susceptibility. However, 
      well‑designed studies with large sample sizes are required for better 
      understanding of this association.
FAU - Chen, B F
AU  - Chen BF
AD  - School of Public Health, Wannan Medical College, Wuhu, China.
FAU - Wang, R
AU  - Wang R
AD  - Department of Health Inspection and Supervision, Wuhu Health Bureau, Wuhu, China.
FAU - Chen, Y J
AU  - Chen YJ
AD  - School of Public Health, Wannan Medical College, Wuhu, China.
FAU - Zhu, Y
AU  - Zhu Y
AD  - School of Public Health, Wannan Medical College, Wuhu, China.
FAU - Ding, L
AU  - Ding L
AD  - School of Public Health, Wannan Medical College, Wuhu, China.
FAU - Wen, Y F
AU  - Wen YF
AD  - School of Public Health, Wannan Medical College, Wuhu, China wyf@wnmc.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20151203
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - *Alleles
MH  - Case-Control Studies
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Odds Ratio
MH  - Polymorphism, Genetic
MH  - Publication Bias
MH  - Tuberculosis/*genetics/microbiology
EDAT- 2015/12/05 06:00
MHDA- 2016/09/16 06:00
CRDT- 2015/12/05 06:00
PHST- 2015/12/05 06:00 [entrez]
PHST- 2015/12/05 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
AID - gmr6765 [pii]
AID - 10.4238/2015.December.1.37 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Dec 3;14(4):15859-68. doi: 10.4238/2015.December.1.37.