PMID- 26634947
OWN - NLM
STAT- MEDLINE
DCOM- 20161220
LR  - 20161230
IS  - 1366-5804 (Electronic)
IS  - 1354-750X (Linking)
VI  - 21
IP  - 2
DP  - 2016
TI  - Cartilage oligomeric matrix protein and hyaluronic acid are sensitive serum 
      biomarkers for early cartilage lesions in the knee joint.
PG  - 146-51
LID - 10.3109/1354750X.2015.1118547 [doi]
AB  - The purpose of this study was to evaluate the relationship between five 
      previously established serum osteoarthritis biomarkers and the severity of 
      cartilage lesions in the knee. Cartilage damage (classified according to the 
      Outerbridge scoring system) and serum concentrations of cartilage oligomeric 
      matrix protein (COMP), collagen type II C-telopeptide (CTX-II), matrix 
      metalloproteinase-3 (MMP-3), collagen type III N-propeptide, (PIIINP), and 
      hyaluronic acid (HA) were determined in 79 patients who underwent knee 
      arthroscopy or total knee replacement. HA and COMP concentrations were 
      significantly higher in the Outerbridge score 1 and 2 groups, respectively. These 
      results suggest that serum COMP and HA concentrations can be used to predict 
      early cartilage lesions in the knee.
FAU - Jiao, Qiang
AU  - Jiao Q
AD  - a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury 
      Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi 
      Province , People's Republic of China and.
FAU - Wei, Lei
AU  - Wei L
AD  - a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury 
      Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi 
      Province , People's Republic of China and.
AD  - b Department of Orthopedics , Rhode Island Hospital, Warren Alpert Medical School 
      of Brown University , Providence , RI , USA.
FAU - Chen, Chongwei
AU  - Chen C
AD  - a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury 
      Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi 
      Province , People's Republic of China and.
FAU - Li, Pengcui
AU  - Li P
AD  - a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury 
      Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi 
      Province , People's Republic of China and.
FAU - Wang, Xiaohu
AU  - Wang X
AD  - a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury 
      Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi 
      Province , People's Republic of China and.
FAU - Li, Yongping
AU  - Li Y
AD  - a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury 
      Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi 
      Province , People's Republic of China and.
FAU - Guo, Li
AU  - Guo L
AD  - a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury 
      Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi 
      Province , People's Republic of China and.
FAU - Zhang, Congming
AU  - Zhang C
AD  - a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury 
      Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi 
      Province , People's Republic of China and.
FAU - Wei, Xiaochun
AU  - Wei X
AD  - a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury 
      Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi 
      Province , People's Republic of China and.
LA  - eng
PT  - Journal Article
DEP - 20151203
PL  - England
TA  - Biomarkers
JT  - Biomarkers : biochemical indicators of exposure, response, and susceptibility to 
      chemicals
JID - 9606000
RN  - 0 (Biomarkers)
RN  - 0 (Cartilage Oligomeric Matrix Protein)
RN  - 0 (Collagen Type II)
RN  - 0 (Peptide Fragments)
RN  - 0 (Procollagen)
RN  - 0 (collagen II C-telopeptide)
RN  - 0 (procollagen Type III-N-terminal peptide)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Arthroplasty, Replacement, Knee
MH  - Arthroscopy
MH  - Biomarkers/*blood
MH  - Cartilage Oligomeric Matrix Protein/*blood
MH  - Collagen Type II/blood
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Hyaluronic Acid/*blood
MH  - Male
MH  - Matrix Metalloproteinase 3/blood
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*blood/diagnosis/surgery
MH  - Peptide Fragments/blood
MH  - Procollagen/blood
MH  - Prognosis
OTO - NOTNLM
OT  - Biomarker
OT  - early cartilage lesion
OT  - knee
OT  - osteoarthritis
EDAT- 2015/12/05 06:00
MHDA- 2016/12/21 06:00
CRDT- 2015/12/05 06:00
PHST- 2015/12/05 06:00 [entrez]
PHST- 2015/12/05 06:00 [pubmed]
PHST- 2016/12/21 06:00 [medline]
AID - 10.3109/1354750X.2015.1118547 [doi]
PST - ppublish
SO  - Biomarkers. 2016;21(2):146-51. doi: 10.3109/1354750X.2015.1118547. Epub 2015 Dec 
      3.