PMID- 2663549
OWN - NLM
STAT- MEDLINE
DCOM- 19890814
LR  - 20190707
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 52
IP  - 1
DP  - 1989 Jul
TI  - Oral immunization with sperm antigens: possible therapy for sperm antibodies?
PG  - 106-12
AB  - Young adult male CD-1 mice were given intraperitoneal injections (IP) of saline 
      (controls) and pooled sperm or seminal plasma of two autoimmune infertile men and 
      two nonautoimmune fertile men (n = 40 per treatment). Other mice received only an 
      oral challenge with the same antigens (oral controls; n = 20 per treatment). 
      Three weeks after the booster challenge (day 36), 20 mice in each group were 
      orally immunized with the antigens, whereas the other 20 were not (IP controls). 
      Cytotoxic antibody titers (immunoglobulin M) to human sperm were significantly 
      higher in mice IP immunized with sperm or seminal plasma from autoimmune 
      infertile men or orally immunized with autoimmune men's sperm, in contrast to the 
      controls. Oral challenge with sperm or seminal plasma of autoimmune infertile men 
      after the IP immunization with the same resulted in significantly decreased 
      cytotoxic sperm antibody titers (P less than 0.001 versus oral or IP controls in 
      sperm immunization; P less than 0.001 versus IP controls in seminal plasma 
      immunization). Fertility was unaffected by any mode of immunization. It is 
      concluded that, in mice, sperm and seminal plasma antigens from autoimmune 
      infertile men are more immunogenic than those from nonautoimmune fertile men, and 
      oral challenge with the former after an IP establishment of cytotoxic sperm 
      immunity desensitizes the immune mice. These findings may have practical 
      implications in the diagnosis and immunotherapy of infertile men with cytotoxic 
      sperm antibodies.
FAU - Congleton, L
AU  - Congleton L
AD  - Department of Urology, Medical University of South Carolina, Charleston.
FAU - Potts, W
AU  - Potts W
FAU - Mathur, S
AU  - Mathur S
LA  - eng
GR  - HD-00450/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Animals
MH  - Autoantibodies/*immunology
MH  - Cytotoxicity, Immunologic
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - *Immunization
MH  - Infertility, Male/*immunology
MH  - Male
MH  - Mice
MH  - Spermatozoa/*immunology
EDAT- 1989/07/01 00:00
MHDA- 1989/07/01 00:01
CRDT- 1989/07/01 00:00
PHST- 1989/07/01 00:00 [pubmed]
PHST- 1989/07/01 00:01 [medline]
PHST- 1989/07/01 00:00 [entrez]
AID - S0015-0282(16)60798-7 [pii]
AID - 10.1016/s0015-0282(16)60798-7 [doi]
PST - ppublish
SO  - Fertil Steril. 1989 Jul;52(1):106-12. doi: 10.1016/s0015-0282(16)60798-7.