PMID- 26635521
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151204
LR  - 20230716
IS  - 1662-5099 (Print)
IS  - 1662-5099 (Electronic)
IS  - 1662-5099 (Linking)
VI  - 8
DP  - 2015
TI  - Early Life Stress Effects on Glucocorticoid-BDNF Interplay in the Hippocampus.
PG  - 68
LID - 10.3389/fnmol.2015.00068 [doi]
LID - 68
AB  - Early life stress (ELS) is implicated in the etiology of multiple psychiatric 
      disorders. Important biological effects of ELS are manifested in 
      stress-susceptible regions of the hippocampus and are partially mediated by 
      long-term effects on glucocorticoid (GC) and/or neurotrophin signaling pathways. 
      GC-signaling mediates the regulation of stress response to maintain homeostasis, 
      while neurotrophin signaling plays a key role in neuronal outgrowth and is 
      crucial for axonal guidance and synaptic integrity. The neurotrophin and 
      GC-signaling pathways co-exist throughout the central nervous system (CNS), 
      particularly in the hippocampus, which has high expression levels of 
      glucocorticoid-receptors (GR) and mineralocorticoid-receptors (MR) as well as 
      brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related 
      kinase receptor B (TrkB). This review addresses the effects of ELS paradigms on 
      GC- and BDNF-dependent mechanisms and their crosstalk in the hippocampus, 
      including potential implications for the pathogenesis of common stress-related 
      disorders.
FAU - Daskalakis, Nikolaos P
AU  - Daskalakis NP
AD  - Traumatic Stress Studies Division and Laboratory of Molecular Neuropsychiatry, 
      Department of Psychiatry, Icahn School of Medicine at Mount Sinai New York, NY, 
      USA ; Mental Health Patient Care Center, James J. Peters Veterans Affairs Medical 
      Center Bronx, NY, USA.
FAU - De Kloet, Edo Ronald
AU  - De Kloet ER
AD  - Department of Medical Pharmacology, Leiden Academic Centre for Drug Research 
      Leiden, Netherlands ; Department of Endocrinology and Metabolism, Leiden 
      University Medical Center, Leiden University Leiden, Netherlands.
FAU - Yehuda, Rachel
AU  - Yehuda R
AD  - Traumatic Stress Studies Division and Laboratory of Molecular Neuropsychiatry, 
      Department of Psychiatry, Icahn School of Medicine at Mount Sinai New York, NY, 
      USA ; Mental Health Patient Care Center, James J. Peters Veterans Affairs Medical 
      Center Bronx, NY, USA ; Department of Neuroscience, Icahn School of Medicine at 
      Mount Sinai New York, NY, USA.
FAU - Malaspina, Dolores
AU  - Malaspina D
AD  - Department of Psychiatry, New York University School of Medicine New York, NY, 
      USA.
FAU - Kranz, Thorsten M
AU  - Kranz TM
AD  - Departments of Cell Biology, Physiology and Neuroscience, and Psychiatry, 
      Skirball Institute of Biomolecular Medicine, New York University New York, NY, 
      USA.
LA  - eng
GR  - RC1 MH088843/MH/NIMH NIH HHS/United States
GR  - RC1 MH088101/MH/NIMH NIH HHS/United States
GR  - R01 NS021072/NS/NINDS NIH HHS/United States
GR  - R01 MH086651/MH/NIMH NIH HHS/United States
GR  - R56 NS021072/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20151116
PL  - Switzerland
TA  - Front Mol Neurosci
JT  - Frontiers in molecular neuroscience
JID - 101477914
PMC - PMC4644789
OTO - NOTNLM
OT  - BDNF
OT  - HPA-axis
OT  - TrkB
OT  - early life stress
OT  - glucocorticoid
OT  - glucocorticoid receptor
OT  - hippocampus
EDAT- 2015/12/05 06:00
MHDA- 2015/12/05 06:01
PMCR- 2015/01/01
CRDT- 2015/12/05 06:00
PHST- 2015/06/02 00:00 [received]
PHST- 2015/10/27 00:00 [accepted]
PHST- 2015/12/05 06:00 [entrez]
PHST- 2015/12/05 06:00 [pubmed]
PHST- 2015/12/05 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnmol.2015.00068 [doi]
PST - epublish
SO  - Front Mol Neurosci. 2015 Nov 16;8:68. doi: 10.3389/fnmol.2015.00068. eCollection 
      2015.