PMID- 26635583
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151204
LR  - 20200929
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 9
DP  - 2015
TI  - Altered Neuronal Firing Pattern of the Basal Ganglia Nucleus Plays a Role in 
      Levodopa-Induced Dyskinesia in Patients with Parkinson's Disease.
PG  - 630
LID - 10.3389/fnhum.2015.00630 [doi]
LID - 630
AB  - BACKGROUND: Levodopa therapy alleviates the symptoms of Parkinson's disease (PD), 
      but long-term treatment often leads to motor complications such as 
      levodopa-induced dyskinesia (LID). AIM: To explore the neuronal activity in the 
      basal ganglia nuclei in patients with PD and LID. METHODS: Thirty patients with 
      idiopathic PD (age, 55.1 +/- 11.0 years; disease duration, 8.7 +/- 5.6 years) were 
      enrolled between August 2006 and August 2013 at the Xuanwu Hospital, Capital 
      Medical University, China. Their Hoehn and Yahr (1967) scores ranged from 2-4 and 
      their UPDRS III scores were 28.5 +/- 5.2. Fifteen of them had severe LID (UPDRS IV 
      scores of 6.7 +/- 1.6). Microelectrode recording was performed in the globus 
      pallidus internus (GPi) and subthalamic nucleus (STN) during pallidotomy (n = 12) 
      or STN deep brain stimulation (DBS; bilateral, n = 12; unilateral, n = 6). The 
      firing patterns and frequencies of various cell types were analyzed by assessing 
      single cell interspike intervals (ISIs) and the corresponding coefficient of 
      variation (CV). RESULTS: A total of 295 neurons were identified from the GPi (n = 
      12) and STN (n = 18). These included 26 (8.8%) highly grouped discharge, 30 
      (10.2%) low frequency firing, 78 (26.4%) rapid tonic discharge, 103 (34.9%) 
      irregular activity, and 58 (19.7%) tremor-related activity. There were 
      significant differences between the two groups (p < 0.05) for neurons with 
      irregular firing, highly irregular cluster-like firing, and low-frequency firing. 
      CONCLUSION: Altered neuronal activity was observed in the basal ganglia nucleus 
      of GPi and STN, and may play important roles in the pathophysiology of PD and 
      LID.
FAU - Li, Xiaoyu
AU  - Li X
AD  - Department of Neurosurgery, Xuanwu Hospital, Capital Medical University Beijing, 
      China.
FAU - Zhuang, Ping
AU  - Zhuang P
AD  - Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical 
      University Beijing, China.
FAU - Li, Yongjie
AU  - Li Y
AD  - Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical 
      University Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20151125
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC4658433
OTO - NOTNLM
OT  - Parkinson's disease
OT  - globus pallidus
OT  - levodopa
OT  - microelectrodes
OT  - movement disorders
OT  - subthalamic nucleus
EDAT- 2015/12/05 06:00
MHDA- 2015/12/05 06:01
PMCR- 2015/01/01
CRDT- 2015/12/05 06:00
PHST- 2015/07/03 00:00 [received]
PHST- 2015/11/04 00:00 [accepted]
PHST- 2015/12/05 06:00 [entrez]
PHST- 2015/12/05 06:00 [pubmed]
PHST- 2015/12/05 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2015.00630 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2015 Nov 25;9:630. doi: 10.3389/fnhum.2015.00630. eCollection 
      2015.