PMID- 26636036
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151204
LR  - 20220129
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 5
DP  - 2015
TI  - Stromal Targets for Fluorescent-Guided Oncologic Surgery.
PG  - 254
LID - 10.3389/fonc.2015.00254 [doi]
LID - 254
AB  - Pre-operative imaging techniques are essential for tumor detection and diagnosis, 
      but offer limited help during surgery. Recently, the applicability of imaging 
      during oncologic surgery has been recognized, using near-infrared fluorescent 
      dyes conjugated to targeting antibodies, peptides, or other vehicles. 
      Image-guided oncologic surgery (IGOS) assists the surgeFon to distinguish tumor 
      from normal tissue during operation, and can aid in recognizing vital structures. 
      IGOS relies on an optimized combination of a dedicated fluorescent camera system 
      and specific probes for targeting. IGOS probes for clinical use are not widely 
      available yet, but numerous pre-clinical studies have been published and clinical 
      trials are being established or prepared. Most of the investigated probes are 
      based on antibodies or peptides against proteins on the membranes of malignant 
      cells, whereas others are directed against stromal cells. Targeting stroma cells 
      for IGOS has several advantages. Besides the high stromal content in more 
      aggressive tumor types, the stroma is often primarily located at the 
      periphery/invasive front of the tumor, which makes stromal targets particularly 
      suited for imaging purposes. Moreover, because stroma up-regulation is a 
      physiological reaction, most proteins to be targeted on these cells are 
      "universal" and not derived from a specific genetic variation, as is the case 
      with many upregulated proteins on malignant cancer cells.
FAU - Boonstra, Martin C
AU  - Boonstra MC
AD  - Department of Surgery, Leiden University Medical Center , Leiden , Netherlands.
FAU - Prakash, Jai
AU  - Prakash J
AD  - Department of Biomaterial Science and Technology, Targeted Therapeutics, 
      University of Twente , Enschede , Netherlands.
FAU - Van De Velde, Cornelis J H
AU  - Van De Velde CJ
AD  - Department of Surgery, Leiden University Medical Center , Leiden , Netherlands.
FAU - Mesker, Wilma E
AU  - Mesker WE
AD  - Department of Surgery, Leiden University Medical Center , Leiden , Netherlands.
FAU - Kuppen, Peter J K
AU  - Kuppen PJ
AD  - Department of Surgery, Leiden University Medical Center , Leiden , Netherlands.
FAU - Vahrmeijer, Alexander L
AU  - Vahrmeijer AL
AD  - Department of Surgery, Leiden University Medical Center , Leiden , Netherlands.
FAU - Sier, Cornelis F M
AU  - Sier CF
AD  - Department of Surgery, Leiden University Medical Center , Leiden , Netherlands ; 
      Antibodies for Research Applications BV , Gouda , Netherlands.
LA  - eng
GR  - 323105/ERC_/European Research Council/International
PT  - Journal Article
PT  - Review
DEP - 20151120
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC4653299
OTO - NOTNLM
OT  - cancer
OT  - imaging
OT  - stroma
OT  - surgery
OT  - targeting
OT  - tumor-associated
EDAT- 2015/12/05 06:00
MHDA- 2015/12/05 06:01
PMCR- 2015/01/01
CRDT- 2015/12/05 06:00
PHST- 2015/08/26 00:00 [received]
PHST- 2015/11/05 00:00 [accepted]
PHST- 2015/12/05 06:00 [entrez]
PHST- 2015/12/05 06:00 [pubmed]
PHST- 2015/12/05 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2015.00254 [doi]
PST - epublish
SO  - Front Oncol. 2015 Nov 20;5:254. doi: 10.3389/fonc.2015.00254. eCollection 2015.