PMID- 26637558
OWN - NLM
STAT- MEDLINE
DCOM- 20160606
LR  - 20221115
IS  - 1522-1539 (Electronic)
IS  - 0363-6135 (Print)
IS  - 0363-6135 (Linking)
VI  - 310
IP  - 3
DP  - 2016 Feb 1
TI  - Aging is associated with changes to the biomechanical properties of the posterior 
      cerebral artery and parenchymal arterioles.
PG  - H365-75
LID - 10.1152/ajpheart.00562.2015 [doi]
AB  - Artery remodeling, described as a change in artery structure, may be responsible 
      for the increased risk of cardiovascular disease with aging. Although the risk 
      for stroke is known to increase with age, relatively young animals have been used 
      in most stroke studies. Therefore, more information is needed on how aging alters 
      the biomechanical properties of cerebral arteries. Posterior cerebral arteries 
      (PCAs) and parenchymal arterioles (PAs) are important in controlling brain 
      perfusion. We hypothesized that aged (22-24 mo old) C57bl/6 mice would have 
      stiffer PCAs and PAs than young (3-5 mo old) mice. The biomechanical properties 
      of the PCAs and PAs were assessed by pressure myography. Data are presented as 
      means +/- SE of young vs. old. In the PCA, older mice had increased outer (155.6 +/- 
      3.2 vs. 169.9 +/- 3.2 mum) and lumen (116.4 +/- 3.6 vs. 137.1 +/- 4.7 mum) diameters. 
      Wall stress (375.6 +/- 35.4 vs. 504.7 +/- 60.0 dyn/cm(2)) and artery stiffness 
      (beta-coefficient: 5.2 +/- 0.3 vs. 7.6 +/- 0.9) were also increased. However, wall 
      strain (0.8 +/- 0.1 vs. 0.6 +/- 0.1) was reduced with age. In the PAs from old mice, 
      wall thickness (3.9 +/- 0.3 vs. 5.1 +/- 0.2 mum) and area (591.1 +/- 95.4 vs. 852.8 +/- 
      100 mum(2)) were increased while stress (758.1 +/- 100.0 vs. 587.2 +/- 35.1 dyn/cm(2)) 
      was reduced. Aging also increased mean arterial and pulse pressures. We conclude 
      that age-associated remodeling occurs in large cerebral arteries and arterioles 
      and may increase the risk of cerebrovascular disease.
CI  - Copyright (c) 2016 the American Physiological Society.
FAU - Diaz-Otero, Janice M
AU  - Diaz-Otero JM
AD  - Department of Pharmacology and Toxicology, Michigan State University, East 
      Lansing, Michigan diazjani@msu.edu.
FAU - Garver, Hannah
AU  - Garver H
AD  - Department of Pharmacology and Toxicology, Michigan State University, East 
      Lansing, Michigan.
FAU - Fink, Gregory D
AU  - Fink GD
AD  - Department of Pharmacology and Toxicology, Michigan State University, East 
      Lansing, Michigan.
FAU - Jackson, William F
AU  - Jackson WF
AD  - Department of Pharmacology and Toxicology, Michigan State University, East 
      Lansing, Michigan.
FAU - Dorrance, Anne M
AU  - Dorrance AM
AD  - Department of Pharmacology and Toxicology, Michigan State University, East 
      Lansing, Michigan.
LA  - eng
GR  - P01 HL070687/HL/NHLBI NIH HHS/United States
GR  - T32 GM092715/GM/NIGMS NIH HHS/United States
GR  - 5T32-GM-092715-04/GM/NIGMS NIH HHS/United States
GR  - P01-HL-070687/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151204
PL  - United States
TA  - Am J Physiol Heart Circ Physiol
JT  - American journal of physiology. Heart and circulatory physiology
JID - 100901228
SB  - IM
MH  - Aging/pathology/*physiology
MH  - Animals
MH  - Arterial Pressure/*physiology
MH  - Arterioles/pathology/physiopathology
MH  - Biomechanical Phenomena
MH  - Blood Pressure/physiology
MH  - Cerebrum/*blood supply
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Myography
MH  - Organ Size
MH  - Posterior Cerebral Artery/pathology/*physiopathology
MH  - Stress, Mechanical
MH  - Vascular Stiffness/*physiology
PMC - PMC4796626
OTO - NOTNLM
OT  - aging
OT  - cerebrovascular circulation
OT  - remodeling
OT  - vasculature
EDAT- 2015/12/08 06:00
MHDA- 2016/06/09 06:00
PMCR- 2017/02/01
CRDT- 2015/12/06 06:00
PHST- 2015/07/17 00:00 [received]
PHST- 2015/12/02 00:00 [accepted]
PHST- 2015/12/06 06:00 [entrez]
PHST- 2015/12/08 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
PHST- 2017/02/01 00:00 [pmc-release]
AID - ajpheart.00562.2015 [pii]
AID - H-00562-2015 [pii]
AID - 10.1152/ajpheart.00562.2015 [doi]
PST - ppublish
SO  - Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H365-75. doi: 
      10.1152/ajpheart.00562.2015. Epub 2015 Dec 4.