PMID- 26638698
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0393-974X (Print)
IS  - 0393-974X (Linking)
VI  - 29
IP  - 2 Suppl 1
DP  - 2015 Apr-Jun
TI  - SERUM IMMUNOGLOBULIN IgE IN A PEDIATRIC POPULATION: A RETROSPECTIVE ANALYSIS.
PG  - 64-9
AB  - Allergic sensitization is mediated by immunoglobulin E (IgE) and an increase of 
      their total value is frequently used to complete a correct diagnosis of atopy. 
      Serum IgE may be considered a typical biomarker for the allergic phenotype. The 
      aim of this study was to evaluate total serum IgE, according to sensitizations 
      and to find a cut off to discriminate between atopic and non-atopic subjects. 
      Seven hundred and ninety-five patients were enrolled in this study. Serum levels 
      of total IgE were measured by a fluorescence immunoassay (ImmunoCAP; 
      ThermoFisher, Uppsala, Sweden) while specific IgE levels were measured by 
      immunofluorometric assay (ImmunoCAP; ThermoFisher, Uppsala, Sweden). Both tests 
      were expressed in kU/L, according to manufacturer’s instructions. RESULTS: A 
      difference for total IgE, according to the gender, has been found (p = 0,0012 ) 
      with higher values for males than for females. A correlation has been found 
      between total IgE and specific IgE, even distinguishing the population in 
      sensitized and non-sensitized. A statistically significant difference has been 
      found according to the presence or the absence of sensitization (p less than 
      0.0001) and also considering mono-sensitized and polysensitized patients (p less 
      than 0.0001). ROC analysis has been performed to define a cut off for total serum 
      IgE, according to sensitization and to the type of sensitization 
      (mono-sensitization or poly-sensitization). Finally multiple regression models 
      have been performed to describe total IgE response (positive or negative) and to 
      predict total IgE values. Since clinical limitations are well known, total IgE 
      provide a useful aid to define atopy, allowing the clinician to carry out further 
      investigations in patients with total IgE values beyond normal limits.
FAU - De Amici, M
AU  - De Amici M
AD  - Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of 
      Pavia, Italy.
FAU - Marseglia, A
AU  - Marseglia A
AD  - Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of 
      Pavia, Italy.
FAU - Licari, A
AU  - Licari A
AD  - Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of 
      Pavia, Italy.
FAU - Caimmi, S
AU  - Caimmi S
AD  - Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of 
      Pavia, Italy.
FAU - Nigrisoli, S
AU  - Nigrisoli S
AD  - Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of 
      Pavia, Italy.
FAU - Torre, C
AU  - Torre C
AD  - Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of 
      Pavia, Italy.
FAU - Testa, G
AU  - Testa G
AD  - Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of 
      Pavia, Italy.
FAU - Marseglia, G L
AU  - Marseglia GL
AD  - Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of 
      Pavia, Italy.
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Biol Regul Homeost Agents
JT  - Journal of biological regulators and homeostatic agents
JID - 8809253
SB  - IM
EDAT- 2015/12/08 06:00
MHDA- 2015/12/08 06:01
CRDT- 2015/12/08 06:00
PHST- 2015/12/08 06:00 [entrez]
PHST- 2015/12/08 06:00 [pubmed]
PHST- 2015/12/08 06:01 [medline]
AID - 11 [pii]
PST - ppublish
SO  - J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2 Suppl 1):64-9.