PMID- 26640385
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151207
LR  - 20220321
IS  - 1178-6930 (Print)
IS  - 1178-6930 (Electronic)
IS  - 1178-6930 (Linking)
VI  - 8
DP  - 2015
TI  - High DEPTOR expression correlates with poor prognosis in patients with esophageal 
      squamous cell carcinoma.
PG  - 3449-55
LID - 10.2147/OTT.S92862 [doi]
AB  - OBJECTIVE: The disheveled, Egl-10, and pleckstrin (DEP) domain containing 
      mammalian target of rapamycin (mTOR)-interacting protein (DEPTOR) is a binding 
      protein containing mTOR complex 1 (mTORC1), mTOR complex 2 (mTORC2), and an 
      endogenous mTOR inhibitor. DEPTOR shows abnormal expressions in numerous types of 
      solid tumors. However, how DEP-TOR is expressed in esophageal squamous cell 
      carcinoma (ESCC) remains elusive. METHODS: The expression of DEPTOR in 220 cases 
      of ESCC and non-cancerous adjacent tissues was detected by immunohistochemistry. 
      DEPTOR levels in ESCC and paired normal tissue were quantified using reverse 
      transcription-polymerase chain reaction and Western blot analysis to verify the 
      immunohistochemical results. The relationship between DEPTOR expression and the 
      clinicopathological features of ESCC was analyzed based on the results of 
      immunohistochemistry. Finally, we analyzed the relationship between DEPTOR 
      expression and the prognosis of patients with ESCC. RESULTS: Immunohistochemical 
      staining showed that the expression rate of DEPTOR in ESCC tissues was 
      significantly increased. DEPTOR mRNA and protein expression was significantly 
      higher in ESCC tissues than in normal adjacent esophageal squamous tissues. High 
      DEPTOR expression was significantly correlated with regional lymph node status in 
      the TNM stage of patients with ESCC. Kaplan-Meier survival curves showed that the 
      rate of overall survival was significantly lower in patients with high DEPTOR 
      expression than in those with low DEPTOR expression. Additionally, high DEPTOR 
      expression was an independent prognostic predictor for ESCC patients. CONCLUSION: 
      High DEPTOR expression is an independent prognostic biomarker indicating a worse 
      prognosis for patients with ESCC.
FAU - Liu, Nan-Bo
AU  - Liu NB
AD  - Department of Thoracic Surgery, Southern Medical University, Guangzhou, People's 
      Republic of China.
FAU - Zhang, Jun-Hua
AU  - Zhang JH
AD  - Department of Anesthesiology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, People's Republic of China.
FAU - Liu, Yu-Fan
AU  - Liu YF
AD  - Department of Thoracic Surgery, Southern Medical University, Guangzhou, People's 
      Republic of China.
FAU - Li, Jun
AU  - Li J
AD  - Department of Thoracic Surgery, The Third Affiliated Hospital of Southern Medical 
      University, Guangzhou, People's Republic of China.
FAU - Zhang, Zhen-Zhong
AU  - Zhang ZZ
AD  - Department of Thoracic Surgery, Southern Medical University, Guangzhou, People's 
      Republic of China.
FAU - Li, Ji-Wei
AU  - Li JW
AD  - Department of Thoracic Surgery, Southern Medical University, Guangzhou, People's 
      Republic of China.
FAU - Liu, Wen-Yue
AU  - Liu WY
AD  - Department of Thoracic Surgery, Southern Medical University, Guangzhou, People's 
      Republic of China.
FAU - Huang, Chen
AU  - Huang C
AD  - Department of Thoracic Surgery, Southern Medical University, Guangzhou, People's 
      Republic of China ; Department of Thoracic Surgery, Fujian Provincial Hospital, 
      Fuzhou, People's Republic of China.
FAU - Shen, Tao
AU  - Shen T
AD  - Department of Thoracic Surgery, Jiangmen Central Hospital, Jiangmen, People's 
      Republic of China.
FAU - Gu, Cheng-Wei
AU  - Gu CW
AD  - Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical 
      University, Xinxiang, People's Republic of China.
FAU - Gao, Dong-Yun
AU  - Gao DY
AD  - Department of Oncology, Dongtai People's Hospital, Dongtai, People's Republic of 
      China.
FAU - Wu, Xia
AU  - Wu X
AD  - Department of Breast Cancer, Affiliated Hospital, Academy of Military Medical 
      Sciences, Beijing, People's Republic of China.
FAU - Wu, Xu
AU  - Wu X
AD  - Department of Thoracic Surgery, Southern Medical University, Guangzhou, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20151119
PL  - New Zealand
TA  - Onco Targets Ther
JT  - OncoTargets and therapy
JID - 101514322
PMC - PMC4657798
OTO - NOTNLM
OT  - DEPTOR
OT  - ESCC
OT  - prognosis
EDAT- 2015/12/08 06:00
MHDA- 2015/12/08 06:01
PMCR- 2015/11/19
CRDT- 2015/12/08 06:00
PHST- 2015/12/08 06:00 [entrez]
PHST- 2015/12/08 06:00 [pubmed]
PHST- 2015/12/08 06:01 [medline]
PHST- 2015/11/19 00:00 [pmc-release]
AID - ott-8-3449 [pii]
AID - 10.2147/OTT.S92862 [doi]
PST - epublish
SO  - Onco Targets Ther. 2015 Nov 19;8:3449-55. doi: 10.2147/OTT.S92862. eCollection 
      2015.