PMID- 26640573
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 10
IP  - 5
DP  - 2015 Nov
TI  - Effects of mitochondrial haplogroup N9a on type 2 diabetes mellitus and its 
      associated complications.
PG  - 1918-1924
AB  - A case-control study was conducted with the aim of identifying the predominant 
      haplogroups associated with type 2 diabetes mellitus (T2DM) and its 
      complications. In addition, the role of N9a in T2DM risk and complications was 
      analyzed. Sequencing of the entire mitochondrial DNA was conducted in 235 
      patients and 244 controls in cohort 1, and six haplogroups (F, B4, D4, D5, M8a 
      and N9a) associated with T2DM were classified. The frequency of N9a was further 
      determined in cohort 2 (440 patients and 244 controls) and examined in two 
      combined cohorts, including 675 patients with T2DM and 649 non-diabetic controls. 
      Multivariate logistic regression analysis and association analysis were performed 
      to investigate the association between genotypes, T2DM and diabetic nephropathy. 
      M8a [P=0.011; odds ratio (OR), 3.49; 95% confidence interval (CI), 1.26-9.69] and 
      haplogroup N9a (P=0.023; OR, 2.60; 95% CI, 1.11-6.05) were associated with an 
      increased risk of T2DM. The frequency of N9a was higher in T2DM patients compared 
      with that in the controls (6.2% vs. 4.3%) and associated with a mild risk 
      (P=0.10; OR, 1.51; 95% CI, 0.92-2.49). N9a was significantly associated with an 
      increased risk of diabetic nephropathy (P=0.024; OR, 2.15; 95% CI, 1.11-4.19). 
      Previous findings of N9a being protective against T2DM were not replicated in the 
      present study, although this haplogroup was associated with an increased risk of 
      diabetic nephropathy.
FAU - Niu, Qing
AU  - Niu Q
AD  - Zhejiang Provincial Key Laboratory of Medical Genetics, Department of 
      Biochemistry and Molecular Biology, Wenzhou Medical University School of 
      Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang 325025, P.R. China.
FAU - Zhang, Wanlin
AU  - Zhang W
AD  - Zhejiang Provincial Key Laboratory of Medical Genetics, Department of 
      Biochemistry and Molecular Biology, Wenzhou Medical University School of 
      Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang 325025, P.R. China.
FAU - Wang, Hailing
AU  - Wang H
AD  - Zhejiang Provincial Key Laboratory of Medical Genetics, Department of 
      Biochemistry and Molecular Biology, Wenzhou Medical University School of 
      Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang 325025, P.R. China.
FAU - Guan, Xiaomin
AU  - Guan X
AD  - Zhejiang Provincial Key Laboratory of Medical Genetics, Department of 
      Biochemistry and Molecular Biology, Wenzhou Medical University School of 
      Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang 325025, P.R. China.
FAU - Lu, Jianxin
AU  - Lu J
AD  - Zhejiang Provincial Key Laboratory of Medical Genetics, Department of 
      Biochemistry and Molecular Biology, Wenzhou Medical University School of 
      Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang 325025, P.R. China.
FAU - Li, Wei
AU  - Li W
AD  - Zhejiang Provincial Key Laboratory of Medical Genetics, Department of 
      Biochemistry and Molecular Biology, Wenzhou Medical University School of 
      Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang 325025, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20150917
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC4665168
OTO - NOTNLM
OT  - M8a
OT  - N9a
OT  - diabetic nephropathy
OT  - mitochondrial genome
OT  - type 2 diabetes mellitus
EDAT- 2015/12/08 06:00
MHDA- 2015/12/08 06:01
PMCR- 2015/09/17
CRDT- 2015/12/08 06:00
PHST- 2015/01/29 00:00 [received]
PHST- 2015/07/13 00:00 [accepted]
PHST- 2015/12/08 06:00 [entrez]
PHST- 2015/12/08 06:00 [pubmed]
PHST- 2015/12/08 06:01 [medline]
PHST- 2015/09/17 00:00 [pmc-release]
AID - ETM-0-0-2751 [pii]
AID - 10.3892/etm.2015.2751 [doi]
PST - ppublish
SO  - Exp Ther Med. 2015 Nov;10(5):1918-1924. doi: 10.3892/etm.2015.2751. Epub 2015 Sep 
      17.