PMID- 26640587
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151207
LR  - 20200929
IS  - 1837-9664 (Print)
IS  - 1837-9664 (Electronic)
IS  - 1837-9664 (Linking)
VI  - 6
IP  - 12
DP  - 2015
TI  - Hsa-miR-301a-3p Acts as an Oncogene in Laryngeal Squamous Cell Carcinoma via 
      Target Regulation of Smad4.
PG  - 1260-75
LID - 10.7150/jca.12659 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant head 
      and neck squamous cell carcinoma. Exploring the molecular indicators of malignant 
      behavior will enhance our knowledge of this type cancer and provide novel options 
      for its prevention, diagnosis, and treatment. MicroRNA might exert regulatory 
      roles as oncogenes or anti-oncogenes. We studied the expression of miR-301a-3p in 
      LSCC tissues and cell lines and conducted a functional analysis of miR-301a-3p to 
      confirm if miR-301a-3p functions as an oncogene in LSCC. We found Smad4 to be one 
      of the potential target genes of miR-301a-3p, and it functioned as a tumor 
      suppressor in LSCC. Hsa-miR-301a-3p participated in the epithelial-mesenchymal 
      transition (EMT) process, which is considered to be linked to the process of LSCC 
      development. Our present findings indicate that miR-301a-3p acts as an oncogene 
      by directly regulating the anti-oncogene Smad4, thereby playing a role in the 
      occurrence and development of LSCC. The present findings are expected to help in 
      the development of novel targets for the prevention and treatment of LSCC.
FAU - Lu, Yan
AU  - Lu Y
AD  - 1. Department of Otolaryngology, Head & Neck Surgery, The First Hospital 
      Affiliated with Shanxi Medical University, Taiyuan, Shanxi, 030001, China ; 3. 
      Department of Otolaryngology, Head & Neck Surgery, The First Hospital Affiliated 
      with Liaoning Medical University, Jinzhou, Liaoning, 121001, China.
FAU - Gao, Wei
AU  - Gao W
AD  - 1. Department of Otolaryngology, Head & Neck Surgery, The First Hospital 
      Affiliated with Shanxi Medical University, Taiyuan, Shanxi, 030001, China ; 2. 
      Shanxi Key Laboratory of Otolaryngology Head & Neck Cancer, Taiyuan, Shanxi, 
      030001, China.
FAU - Zhang, Chunming
AU  - Zhang C
AD  - 1. Department of Otolaryngology, Head & Neck Surgery, The First Hospital 
      Affiliated with Shanxi Medical University, Taiyuan, Shanxi, 030001, China ; 2. 
      Shanxi Key Laboratory of Otolaryngology Head & Neck Cancer, Taiyuan, Shanxi, 
      030001, China.
FAU - Wen, Shuxin
AU  - Wen S
AD  - 1. Department of Otolaryngology, Head & Neck Surgery, The First Hospital 
      Affiliated with Shanxi Medical University, Taiyuan, Shanxi, 030001, China ; 2. 
      Shanxi Key Laboratory of Otolaryngology Head & Neck Cancer, Taiyuan, Shanxi, 
      030001, China.
FAU - Huangfu, Hui
AU  - Huangfu H
AD  - 1. Department of Otolaryngology, Head & Neck Surgery, The First Hospital 
      Affiliated with Shanxi Medical University, Taiyuan, Shanxi, 030001, China ; 2. 
      Shanxi Key Laboratory of Otolaryngology Head & Neck Cancer, Taiyuan, Shanxi, 
      030001, China.
FAU - Kang, Jian
AU  - Kang J
AD  - 3. Department of Otolaryngology, Head & Neck Surgery, The First Hospital 
      Affiliated with Liaoning Medical University, Jinzhou, Liaoning, 121001, China.
FAU - Wang, Binquan
AU  - Wang B
AD  - 1. Department of Otolaryngology, Head & Neck Surgery, The First Hospital 
      Affiliated with Shanxi Medical University, Taiyuan, Shanxi, 030001, China ; 2. 
      Shanxi Key Laboratory of Otolaryngology Head & Neck Cancer, Taiyuan, Shanxi, 
      030001, China.
LA  - eng
PT  - Journal Article
DEP - 20151020
PL  - Australia
TA  - J Cancer
JT  - Journal of Cancer
JID - 101535920
PMC - PMC4643083
OTO - NOTNLM
OT  - Hsa-miR-301a-3p
OT  - Laryngeal neoplasms
OT  - MicroRNAs
OT  - Smad4
OT  - Squamous cell carcinoma
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2015/12/08 06:00
MHDA- 2015/12/08 06:01
PMCR- 2015/01/01
CRDT- 2015/12/08 06:00
PHST- 2015/05/11 00:00 [received]
PHST- 2015/08/28 00:00 [accepted]
PHST- 2015/12/08 06:00 [entrez]
PHST- 2015/12/08 06:00 [pubmed]
PHST- 2015/12/08 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - jcav06p1260 [pii]
AID - 10.7150/jca.12659 [doi]
PST - epublish
SO  - J Cancer. 2015 Oct 20;6(12):1260-75. doi: 10.7150/jca.12659. eCollection 2015.