PMID- 26641254
OWN - NLM
STAT- MEDLINE
DCOM- 20160627
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 12
DP  - 2015
TI  - Association between Single-Nucleotide Polymorphisms of the Tyrosine Kinase 
      Receptor B (TrkB) and Post-Stroke Depression in China.
PG  - e0144301
LID - 10.1371/journal.pone.0144301 [doi]
LID - e0144301
AB  - BACKGROUND: Polymorphisms of the brain-derived neurotrophic factor (BDNF) have 
      been investigated as candidate genes for post-stroke depression (PSD), and its 
      receptor, neurotrophic tyrosine kinase receptor B (TrkB), has been associated 
      with depression. However, no further data have yet reported the association 
      between PSD and polymorphisms in TrkB. This study aims to investigate whether a 
      relationship exists between TrkB polymorphisms and PSD. METHODS: A total of 312 
      depression patients (PSD patients) and 472 non-depression patient controls (NPSD 
      patients) were recruited. All patients were evaluated using the Hamilton Rating 
      Scale for Depression (HAMD) to determine depression severity, and PSD patients 
      were diagnosed in accordance with DSM-V criteria. Three single-nucleotide 
      polymorphisms (SNPs), namely, rs1187323, rs1212171, and rs1778929, in the TrkB 
      gene were genotyped by high-resolution melt analysis. RESULTS: The SNP rs1778929 
      was significantly more associated with incident PSD in participants with the TT 
      genotype than in those with CC (OR 0.482, 95% CI: 0.313-0.744). In terms of 
      rs1187323, stroke was significantly more associated with incident depression in 
      participants with the AC genotype than in those with AA (OR 0.500, 95% CI: 
      0.368-0.680). The minor allele (T) of rs1778929 (P = 0.024, OR = 0.725, 95% CI = 
      0.590-0.890) and the minor allele (C) of rs1187323 (P = 0.000, OR = 0.598, 95% CI 
      = 0.466-0.767) were found to be significantly associated with PSD. Neither 
      genotype nor allele frequencies of rs1212171 showed statistically significant 
      differences between PSD and NPSD patients. CONCLUSIONS: The results suggest that 
      rs1778929 and rs1187323 in the TrkB gene are significantly associated with 
      post-stroke depression in the Chinese population. Further studies are necessary 
      to confirm our findings.
FAU - Zhou, Zhiming
AU  - Zhou Z
AD  - Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 
      Province, P.R. China.
FAU - Ding, Xianhui
AU  - Ding X
AD  - Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 
      Province, P.R. China.
FAU - Yang, Qian
AU  - Yang Q
AD  - Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 
      Province, P.R. China.
FAU - Hu, Jia
AU  - Hu J
AD  - Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 
      Province, P.R. China.
FAU - Shang, Xianjin
AU  - Shang X
AD  - Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 
      Province, P.R. China.
FAU - Huang, Xianjun
AU  - Huang X
AD  - Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 
      Province, P.R. China.
FAU - Ge, Liang
AU  - Ge L
AD  - Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 
      Province, P.R. China.
FAU - Zhou, Taofeng
AU  - Zhou T
AD  - Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 
      Province, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151207
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Membrane Glycoproteins)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (tropomyosin-related kinase-B, human)
SB  - IM
MH  - Aged
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - China
MH  - Depression/epidemiology/etiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Protein-Tyrosine Kinases/*genetics
MH  - Receptor, trkB
MH  - Stroke/complications/*psychology
PMC - PMC4671559
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/12/08 06:00
MHDA- 2016/06/28 06:00
PMCR- 2015/12/07
CRDT- 2015/12/08 06:00
PHST- 2015/08/24 00:00 [received]
PHST- 2015/11/16 00:00 [accepted]
PHST- 2015/12/08 06:00 [entrez]
PHST- 2015/12/08 06:00 [pubmed]
PHST- 2016/06/28 06:00 [medline]
PHST- 2015/12/07 00:00 [pmc-release]
AID - PONE-D-15-37036 [pii]
AID - 10.1371/journal.pone.0144301 [doi]
PST - epublish
SO  - PLoS One. 2015 Dec 7;10(12):e0144301. doi: 10.1371/journal.pone.0144301. 
      eCollection 2015.