PMID- 26643911
OWN - NLM
STAT- MEDLINE
DCOM- 20161011
LR  - 20161230
IS  - 1479-6813 (Electronic)
IS  - 0952-5041 (Linking)
VI  - 56
IP  - 2
DP  - 2016 Feb
TI  - Maternal high-fat diet influences stroke outcome in adult rat offspring.
PG  - 101-12
LID - 10.1530/JME-15-0226 [doi]
AB  - Diet-induced epigenetic modifications in early life could contribute to later 
      health problem. However, it remains to be established whether high-fat diet (HFD) 
      consumption during pregnancy and the suckling period could predispose the 
      offspring to stroke. The present study investigated the influence of maternal HFD 
      on stroke outcome in adult offspring. Female Sprague-Dawley rats were fed a 
      normal diet (5.3% fat) or a HFD (25.7% fat), just before pregnancy until the end 
      of lactation. Male offspring were fed with the control diet or the HFD after 
      weaning, to form four groups (control offspring fed with the control diet (C/C) 
      or the HFD (C/HFD) and offspring of fat-fed dams fed with the control diet 
      (HFD/C) or the HFD (HFD/HFD)). The offspring received middle cerebral artery 
      occlusion on day 120 followed by behavioral tests (neurological deficit score, 
      staircase-reaching test and beam-traversing test), and infarct volumes were also 
      calculated. We found that the HFD/C rats displayed larger infarct volume and 
      aggravated functional deficits (all P<0.05), compared with the C/C rats, 
      indicating that maternal fat-rich diet renders the brain more susceptible to the 
      consequences of ischemic injury. Moreover, maternal HFD offspring displayed 
      elevated glucocorticoid concentrations following stroke, and increased 
      glucocorticoid receptor expression. In addition, adrenalectomy reversed the 
      effects of maternal HFD on stroke outcome when corticosterone was replaced at 
      baseline, but not ischemic, concentrations. Furthermore, expression of 
      brain-derived neurotrophic factor (BDNF) in the ipsilateral hippocampus was 
      decreased in the HFD/C offspring (P<0.05), compared with the C/C offspring. Taken 
      together, maternal diet can substantially influence adult cerebrovascular health, 
      through the programming of central BDNF expression and the 
      hypothalamic-pituitary-adrenal axis.
CI  - (c) 2016 Society for Endocrinology.
FAU - Lin, ChengCheng
AU  - Lin C
AD  - Department of Surgery LaboratoryFirst Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, ChinaFirst Department of Neurology, First Affiliated 
      Hospital of Wenzhou Medical UniversityWenzhou 325000, China.
FAU - Shao, Bei
AU  - Shao B
AD  - Department of Surgery LaboratoryFirst Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, ChinaFirst Department of Neurology, First Affiliated 
      Hospital of Wenzhou Medical UniversityWenzhou 325000, China.
FAU - Zhou, YuLei
AU  - Zhou Y
AD  - Department of Surgery LaboratoryFirst Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, ChinaFirst Department of Neurology, First Affiliated 
      Hospital of Wenzhou Medical UniversityWenzhou 325000, China.
FAU - Niu, XiaoTing
AU  - Niu X
AD  - Department of Surgery LaboratoryFirst Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, ChinaFirst Department of Neurology, First Affiliated 
      Hospital of Wenzhou Medical UniversityWenzhou 325000, China.
FAU - Lin, YuanShao
AU  - Lin Y
AD  - Department of Surgery LaboratoryFirst Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, ChinaFirst Department of Neurology, First Affiliated 
      Hospital of Wenzhou Medical UniversityWenzhou 325000, China 
      linyuanshao@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151207
PL  - England
TA  - J Mol Endocrinol
JT  - Journal of molecular endocrinology
JID - 8902617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Glucocorticoid)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Corticosterone/blood
MH  - Diet, High-Fat/*adverse effects
MH  - Disease Susceptibility
MH  - Female
MH  - Gene Expression
MH  - Hippocampus/blood supply/metabolism/*pathology
MH  - Infarction, Middle Cerebral Artery/blood/etiology/*pathology
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/blood/etiology/*pathology
MH  - Prenatal Nutritional Physiological Phenomena
MH  - Rats, Sprague-Dawley
MH  - Receptors, Glucocorticoid/genetics/metabolism
OTO - NOTNLM
OT  - corticosterone, brain-derived neurotrophic factor
OT  - early life
OT  - high-fat diet
OT  - stroke
EDAT- 2015/12/09 06:00
MHDA- 2016/10/12 06:00
CRDT- 2015/12/09 06:00
PHST- 2015/12/03 00:00 [accepted]
PHST- 2015/12/09 06:00 [entrez]
PHST- 2015/12/09 06:00 [pubmed]
PHST- 2016/10/12 06:00 [medline]
AID - JME-15-0226 [pii]
AID - 10.1530/JME-15-0226 [doi]
PST - ppublish
SO  - J Mol Endocrinol. 2016 Feb;56(2):101-12. doi: 10.1530/JME-15-0226. Epub 2015 Dec 
      7.