PMID- 26644185 OWN - NLM STAT- MEDLINE DCOM- 20160919 LR - 20190606 IS - 1643-3750 (Electronic) IS - 1234-1010 (Print) IS - 1234-1010 (Linking) VI - 21 DP - 2015 Dec 8 TI - High Blood Glucose Levels Correlate with Tumor Malignancy in Colorectal Cancer Patients. PG - 3825-33 AB - BACKGROUND Research shows that type 2 diabetes mellitus (T2DM) affects the risk and prognosis of colorectal cancer (CRC). Here, we conducted a retrospective study to investigate whether the clinicopathological features of CRC patients correlate with their blood glucose levels. MATERIAL AND METHODS We enrolled 391 CRC patients hospitalized in our center between 2008 and 2013. Data of their first fasting plasma glucose (FPG) and 2-h postprandial glucose (2hPPG) level after admission, their clinicopathological features, and survival were collected. The correlations between blood glucose level and clinicopathological features were analyzed by Pearson chi-square analysis. Patient survival was analyzed by Kaplan-Meier and Cox-regression analysis. RESULTS There were 116 out of the 391 CRC patients who had high blood glucose level (H-G group, 29.67%), among which 58 (14.83%), 18 (4.60%), and 40 (10.23%) were diabetes mellitus (DM), impaired glucose tolerance (IGT), and impaired fasting glucose (IFG), respectively, while 275 (70.33%) patients had normal glucose level (N-G group). Compared with the N-G group, patients in the H-G group had larger tumor diameters and lower tumor differentiation (p<0.05). A higher ratio of patients in the H-G group also had more advanced TNM staging and more ulcerative CRC gross type (p<0.05). No significant difference was observed in patient overall survival among different glucose groups. No effect of insulin therapy on CRC development and patient survival was observed. CONCLUSIONS Blood glucose level in CRC patients correlates significantly with local tumor malignancy, but no significant effect on distant metastasis and patient overall survival was observed. FAU - Cui, Ge AU - Cui G AD - Department of Oncology, The First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China (mainland). FAU - Zhang, Ting AU - Zhang T AD - School of Medicine, Huzhou University, Huzhou, Zhejiang, China (mainland). FAU - Ren, Fan AU - Ren F AD - Department of Oncology, The First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China (mainland). FAU - Feng, Wen-Ming AU - Feng WM AD - Department of Oncology, The First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China (mainland). FAU - Yao, Yunliang AU - Yao Y AD - School of Medicine, Huzhou University, Huzhou, Zhejiang, China (mainland). FAU - Cui, Jie AU - Cui J AD - School of Medicine, Zibo Hospital of Traditional Chinese Medicine, Zibo, Shangdong, China (mainland). FAU - Zhu, Guo-Liang AU - Zhu GL AD - Department of Oncology, The First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China (mainland). FAU - Shi, Qi-Lin AU - Shi QL AD - Department of Oncology, The First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China (mainland). LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20151208 PL - United States TA - Med Sci Monit JT - Medical science monitor : international medical journal of experimental and clinical research JID - 9609063 RN - 0 (Blood Glucose) SB - IM MH - Blood Glucose/*metabolism MH - Colorectal Neoplasms/blood/complications/*pathology MH - Diabetes Mellitus/blood MH - Female MH - Glucose Tolerance Test MH - Humans MH - Male MH - Middle Aged MH - Survival Analysis PMC - PMC4677694 EDAT- 2015/12/09 06:00 MHDA- 2016/09/20 06:00 PMCR- 2015/12/08 CRDT- 2015/12/09 06:00 PHST- 2015/12/09 06:00 [entrez] PHST- 2015/12/09 06:00 [pubmed] PHST- 2016/09/20 06:00 [medline] PHST- 2015/12/08 00:00 [pmc-release] AID - 894783 [pii] AID - 10.12659/msm.894783 [doi] PST - epublish SO - Med Sci Monit. 2015 Dec 8;21:3825-33. doi: 10.12659/msm.894783.