PMID- 26644513
OWN - NLM
STAT- MEDLINE
DCOM- 20160405
LR  - 20230916
IS  - 1540-8140 (Electronic)
IS  - 0021-9525 (Print)
IS  - 0021-9525 (Linking)
VI  - 211
IP  - 5
DP  - 2015 Dec 7
TI  - Vitamin D receptor-retinoid X receptor heterodimer signaling regulates 
      oligodendrocyte progenitor cell differentiation.
PG  - 975-85
LID - 10.1083/jcb.201505119 [doi]
AB  - The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor 
      cells (OPCs) into mature OLGs are key to understanding myelination and 
      remyelination. Signaling via the retinoid X receptor gamma (RXR-gamma) has been shown to 
      be a positive regulator of OPC differentiation. However, the nuclear receptor 
      (NR) binding partner of RXR-gamma has not been established. In this study we show 
      that RXR-gamma binds to several NRs in OPCs and OLGs, one of which is vitamin D 
      receptor (VDR). Using pharmacological and knockdown approaches we show that 
      RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D 
      enhances OPC differentiation. We also show expression of VDR in OLG lineage cells 
      in multiple sclerosis. Our data reveal a role for vitamin D in the regenerative 
      component of demyelinating disease and identify a new target for remyelination 
      medicines.
CI  - (c) 2015 de la Fuente et al.
FAU - de la Fuente, Alerie Guzman
AU  - de la Fuente AG
AD  - Wellcome Trust-Medical Research Council Stem Cell Institute, University of 
      Cambridge, Cambridge CB2 0AH, England, UK.
FAU - Errea, Oihana
AU  - Errea O
AD  - Wellcome Trust-Medical Research Council Stem Cell Institute, University of 
      Cambridge, Cambridge CB2 0AH, England, UK.
FAU - van Wijngaarden, Peter
AU  - van Wijngaarden P
AD  - Wellcome Trust-Medical Research Council Stem Cell Institute, University of 
      Cambridge, Cambridge CB2 0AH, England, UK Centre for Eye Research, University of 
      Melbourne, Royal Victorian Eye and Ear Hospital, Victoria 3002, Australia.
FAU - Gonzalez, Ginez A
AU  - Gonzalez GA
AD  - Wellcome Trust-Medical Research Council Stem Cell Institute, University of 
      Cambridge, Cambridge CB2 0AH, England, UK.
FAU - Kerninon, Christophe
AU  - Kerninon C
AD  - Institut du Cerveau et de la Moelle Epiniere, Institut National de la Sante et de 
      la Recherche Medicale, Unite Mixte de Recherche 1127, 75651 Paris, France.
FAU - Jarjour, Andrew A
AU  - Jarjour AA
AD  - Medical Research Council Centre for Regenerative Medicine, University of 
      Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
FAU - Lewis, Hilary J
AU  - Lewis HJ
AD  - AstraZeneca, Great Abington CB21 6GH, England, UK.
FAU - Jones, Clare A
AU  - Jones CA
AD  - AstraZeneca, Great Abington CB21 6GH, England, UK.
FAU - Nait-Oumesmar, Brahim
AU  - Nait-Oumesmar B
AD  - Institut du Cerveau et de la Moelle Epiniere, Institut National de la Sante et de 
      la Recherche Medicale, Unite Mixte de Recherche 1127, 75651 Paris, France.
FAU - Zhao, Chao
AU  - Zhao C
AD  - Wellcome Trust-Medical Research Council Stem Cell Institute, University of 
      Cambridge, Cambridge CB2 0AH, England, UK.
FAU - Huang, Jeffrey K
AU  - Huang JK
AD  - Department of Biology, Georgetown University, Washington, DC 20057.
FAU - ffrench-Constant, Charles
AU  - ffrench-Constant C
AD  - Medical Research Council Centre for Regenerative Medicine, University of 
      Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
FAU - Franklin, Robin J M
AU  - Franklin RJ
AD  - Wellcome Trust-Medical Research Council Stem Cell Institute, University of 
      Cambridge, Cambridge CB2 0AH, England, UK rjf1000@cam.ac.uk.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 104783/WT_/Wellcome Trust/United Kingdom
GR  - 97922/WT_/Wellcome Trust/United Kingdom
GR  - MC_PC_12012/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (Retinoid X Receptor gamma)
RN  - 0 (VDR protein, human)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Female
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*metabolism
MH  - Myelin Sheath/chemistry
MH  - Oligodendroglia/*cytology
MH  - Protein Binding
MH  - Protein Multimerization
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Calcitriol/*metabolism
MH  - Retinoid X Receptor gamma/*metabolism
MH  - Signal Transduction
MH  - Stem Cells/*cytology
MH  - Vitamin D/metabolism
PMC - PMC4674280
EDAT- 2015/12/09 06:00
MHDA- 2016/04/06 06:00
PMCR- 2016/06/07
CRDT- 2015/12/09 06:00
PHST- 2015/12/09 06:00 [entrez]
PHST- 2015/12/09 06:00 [pubmed]
PHST- 2016/04/06 06:00 [medline]
PHST- 2016/06/07 00:00 [pmc-release]
AID - jcb.201505119 [pii]
AID - 201505119 [pii]
AID - 10.1083/jcb.201505119 [doi]
PST - ppublish
SO  - J Cell Biol. 2015 Dec 7;211(5):975-85. doi: 10.1083/jcb.201505119.