PMID- 26644738
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151208
LR  - 20200929
IS  - 0974-2077 (Print)
IS  - 0974-5157 (Electronic)
IS  - 0974-2077 (Linking)
VI  - 8
IP  - 3
DP  - 2015 Jul-Sep
TI  - A Prospective, Comparative, Evaluator-blind Clinical Study Investigating Efficacy 
      and Safety of Two Injection Techniques with Radiesse((R)) for the Correction of 
      Skin Changes in Aging Hands.
PG  - 147-52
LID - 10.4103/0974-2077.167271 [doi]
AB  - BACKGROUND: Dermal fillers are used to correct age-related changes in hands. 
      AIMS: Assess efficacy and safety of two injection techniques to treat age-related 
      changes in the hands using calcium hydroxylapatite filler, Radiesse((R)). SETTINGS 
      AND DESIGN: This was a prospective, comparative, evaluator-blind, single-center 
      study. MATERIALS AND METHODS: Radiesse((R)) (0.8 mL/0.2 mL 2% lidocaine) was 
      injected subdermally on Day (D)01, using a needle multipoint technique in one 
      hand (N) and a fan-like cannula technique in the other (C). Assessments were made 
      pre-injection, on D14, Month (M)02, M03 and M05 using the Merz Aesthetics Hand 
      Grading Scale (MAS) and Global Aesthetic Improvement Scale (GAIS). Participants 
      completed questionnaires on satisfaction, pain and adverse events (AEs). 
      STATISTICAL ANALYSIS USED: Data distribution was tested with the Shapiro-Wilk and 
      Levene's tests. The Wilcoxon signed-rank and Chi-square tests were employed to 
      evaluate quantitative and qualitative data, respectively. RESULTS: All 10 
      participants completed the study, four opted for a M03 touch-up (0.8 mL 
      Radiesse((R))). Evaluator-assessed mean GAIS scores were between 2 (significant 
      improvement but not complete correction) and 3 (optimal cosmetic result) at each 
      time point. The MAS score improved from D01 to M05 (N: 2.60 to 1.40; C: 2.20 to 
      1.30). Following treatment, participants reported skin was softer, more elastic, 
      more youthful and less wrinkled. Other than less noticeable veins and tendons on 
      the C hand, no differences in participant satisfaction were noted. All AEs were 
      mild, with no serious AEs reported. CONCLUSIONS: Both injection techniques 
      (needle and cannula) demonstrated equivalent clinical efficacy with a comparable 
      safety profile for the correction of age-related changes in hands with 
      Radiesse((R)).
FAU - Gubanova, Elena I
AU  - Gubanova EI
AD  - Vallex M Clinic of Preventive Medicine, Moscow National University of Food 
      Production, Moscow, Russia ; Department of Skin and Venereal Diseases, 
      Postgraduate Medical Institute, Moscow National University of Food Production, 
      Moscow, Russia.
FAU - Starovatova, Polina A
AU  - Starovatova PA
AD  - Vallex M Clinic of Preventive Medicine, Moscow National University of Food 
      Production, Moscow, Russia ; Department of Skin and Venereal Diseases, 
      Postgraduate Medical Institute, Moscow National University of Food Production, 
      Moscow, Russia.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Cutan Aesthet Surg
JT  - Journal of cutaneous and aesthetic surgery
JID - 101525405
PMC - PMC4645144
OTO - NOTNLM
OT  - Age-related skin changes
OT  - Radiesse(R)
OT  - calcium hydroxylapatite
OT  - cannula
OT  - dermal filler
OT  - hand rejuvenation
OT  - needle
COIS- Conflicts of Interest: EIG is a scientific advisory board member for Ipsen, an 
      international trainer for Restylane((R)) (Q-MED) and is a consultant for Merz 
      Russia. PAS has no conflicts to disclose.
EDAT- 2015/12/09 06:00
MHDA- 2015/12/09 06:01
PMCR- 2015/07/01
CRDT- 2015/12/09 06:00
PHST- 2015/12/09 06:00 [entrez]
PHST- 2015/12/09 06:00 [pubmed]
PHST- 2015/12/09 06:01 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - JCAS-8-147 [pii]
AID - 10.4103/0974-2077.167271 [doi]
PST - ppublish
SO  - J Cutan Aesthet Surg. 2015 Jul-Sep;8(3):147-52. doi: 10.4103/0974-2077.167271.