PMID- 26644772
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151208
LR  - 20200929
IS  - 1308-8734 (Print)
IS  - 1308-8742 (Electronic)
IS  - 1308-8734 (Linking)
VI  - 47
IP  - 3
DP  - 2015 Oct
TI  - New-Onset Diabetes Mellitus Associated with Sirolimus Use in Renal Transplant 
      Recipients.
PG  - 213-5
LID - 10.5152/eurasianjmed.2015.049 [doi]
AB  - New-onset diabetes after transplantation and impaired glucose tolerance are very 
      common in renal transplant patients. New-onset diabetes after transplantation 
      (NODAT) is associated with increased cardiovascular morbidity and mortality, 
      reduced graft and patient survival. Several risk factors for NODAT have been 
      identified: age, obesity, family history of diabetes mellitus and HCV infection. 
      In addition, steroid and calcineurin inhibitors also contribute to the 
      development of NODAT. Sirolimus causes immunosuppressive effects by inhibiting 
      mammalian target of rapamycin (mTOR), and has well known side effects. The 
      effects of sirolimus on glucose metabolism and contribution to NODAT development 
      are not clearly known. In this report, we presented five RTX patients who 
      developed NODAT under the treatment of sirolimus.
FAU - Yilmaz, Vural Taner
AU  - Yilmaz VT
AD  - Department of Internal Medicine, Division of Nephrology, Akdeniz University 
      School of Medicine, Antalya, Turkey.
FAU - Kocak, Huseyin
AU  - Kocak H
AD  - Department of Internal Medicine, Division of Nephrology, Akdeniz University 
      School of Medicine, Antalya, Turkey.
FAU - Dinckan, Ayhan
AU  - Dinckan A
AD  - Department of General Surgery, Akdeniz University School of Medicine, Antalya, 
      Turkey.
FAU - Cetinkaya, Ramazan
AU  - Cetinkaya R
AD  - Department of Internal Medicine, Division of Nephrology, Akdeniz University 
      School of Medicine, Antalya, Turkey.
LA  - eng
PT  - Case Reports
PL  - Turkey
TA  - Eurasian J Med
JT  - The Eurasian journal of medicine
JID - 101557701
CIN - Eurasian J Med. 2016 Oct;48(3):234. PMID: 28149155
PMC - PMC4659525
OTO - NOTNLM
OT  - Renal transplantation
OT  - diabetes mellitus
OT  - sirolimus
EDAT- 2015/12/09 06:00
MHDA- 2015/12/09 06:01
PMCR- 2015/10/01
CRDT- 2015/12/09 06:00
PHST- 2015/12/09 06:00 [entrez]
PHST- 2015/12/09 06:00 [pubmed]
PHST- 2015/12/09 06:01 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - eajm-47-3-213 [pii]
AID - 10.5152/eurasianjmed.2015.049 [doi]
PST - ppublish
SO  - Eurasian J Med. 2015 Oct;47(3):213-5. doi: 10.5152/eurasianjmed.2015.049.