PMID- 26645280
OWN - NLM
STAT- MEDLINE
DCOM- 20170614
LR  - 20181113
IS  - 1558-9307 (Electronic)
IS  - 0024-4201 (Linking)
VI  - 51
IP  - 5
DP  - 2016 May
TI  - High-Fat Diets Containing Different Amounts of n3 and n6 Polyunsaturated Fatty 
      Acids Modulate Inflammatory Cytokine Production in Mice.
PG  - 571-82
LID - 10.1007/s11745-015-4093-x [doi]
AB  - Dysregulation of adipokines is a hallmark of obesity. Polyunsaturated fatty acids 
      in fish oil may exert anti-inflammatory effects on adipose tissue mitigating the 
      dysregulation of adipokines thereby preventing obesity. This study investigated 
      the effects of high-fat diets containing different amounts of n3 polyunsaturated 
      fatty acids (PUFA) on adiposity and adipokine production in mice. Mice were fed a 
      low-fat or a high-fat diet with 16 or 45 % of energy from corn oil (low n3 PUFA) 
      in comparison with a high-fat diet containing soybean or high-oleic sunflower oil 
      (adequate n3 PUFA) or flaxseed or fish oil (high n3 PUFA) for 11 weeks. High-fat 
      diets, regardless of types of oils, significantly increased body fat mass and 
      body weights compared to the low-fat diet. Adipose fatty acid composition and 
      contents reflected dietary fatty acid profiles. The high-fat fish oil diet 
      significantly increased adiponectin and reduced leptin concentrations in both 
      plasma and adipose tissue; it did not elevate plasma insulin concentration 
      compared to the high-fat corn oil diet. All high-fat diets elevated 
      concentrations of plasminogen activator inhibitor-1 (PAI-1) and monocyte 
      chemoattractant protein-1 (MCP-1) but lowered resistin concentrations in both 
      plasma and adipose tissue. In conclusion, fish oil may be beneficial in improving 
      insulin sensitivity by upregulation of adiponectin and downregulation of leptin 
      production; n3 and n6 PUFA do not play a role at the dietary levels tested in 
      reducing adiposity and production of pro-inflammatory cytokines (leptin, PAI-1, 
      MCP-1 and resistin) and anti-inflammatory cytokine adiponectin.
FAU - Sundaram, Sneha
AU  - Sundaram S
AD  - U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human 
      Nutrition Research Center, 2420 2nd Avenue North, Grand Forks, ND, 58202, USA.
FAU - Bukowski, Michael R
AU  - Bukowski MR
AD  - U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human 
      Nutrition Research Center, 2420 2nd Avenue North, Grand Forks, ND, 58202, USA.
FAU - Lie, Wen-Rong
AU  - Lie WR
AD  - EMD Millipore Corporation, St. Charles, MO, 63304, USA.
FAU - Picklo, Matthew J
AU  - Picklo MJ
AD  - U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human 
      Nutrition Research Center, 2420 2nd Avenue North, Grand Forks, ND, 58202, USA.
FAU - Yan, Lin
AU  - Yan L
AD  - U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human 
      Nutrition Research Center, 2420 2nd Avenue North, Grand Forks, ND, 58202, USA. 
      lin.yan@ars.usda.gov.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20151208
PL  - United States
TA  - Lipids
JT  - Lipids
JID - 0060450
RN  - 0 (Adipokines)
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Omega-6)
RN  - 0 (Insulin)
SB  - IM
MH  - Adipokines/analysis/blood/*immunology
MH  - Adipose Tissue/chemistry/immunology
MH  - *Adiposity
MH  - Animals
MH  - *Diet, High-Fat/adverse effects
MH  - Dietary Fats, Unsaturated/analysis/*immunology
MH  - Energy Intake
MH  - Fatty Acids, Omega-3/analysis/*immunology
MH  - Fatty Acids, Omega-6/analysis/*immunology
MH  - Insulin/analysis/blood/immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/immunology
OTO - NOTNLM
OT  - Adipokines
OT  - Adiposity
OT  - Mice
OT  - Obesity
OT  - Polyunsaturated fatty acids
EDAT- 2015/12/10 06:00
MHDA- 2017/06/15 06:00
CRDT- 2015/12/10 06:00
PHST- 2015/07/29 00:00 [received]
PHST- 2015/11/05 00:00 [accepted]
PHST- 2015/12/10 06:00 [entrez]
PHST- 2015/12/10 06:00 [pubmed]
PHST- 2017/06/15 06:00 [medline]
AID - 10.1007/s11745-015-4093-x [pii]
AID - 10.1007/s11745-015-4093-x [doi]
PST - ppublish
SO  - Lipids. 2016 May;51(5):571-82. doi: 10.1007/s11745-015-4093-x. Epub 2015 Dec 8.