PMID- 26646000
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181202
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 41
IP  - 5
DP  - 2016 May
TI  - P7C3 Attenuates the Scopolamine-Induced Memory Impairments in C57BL/6J Mice.
PG  - 1010-9
LID - 10.1007/s11064-015-1783-y [doi]
AB  - Memory impairment is the most common symptom in patients with Alzheimer's 
      disease. The purpose of this study is to evaluate the memory enhancing effects of 
      P7C3, a recently identified compound with robust proneurogenic and 
      neuroprotective effects, on the cognitive impairment induced by scopolamine, a 
      muscarinic acetylcholine receptor antagonist. Different behavior tests including 
      the Y-maze, Morris water maze, and passive avoidance tests were performed to 
      measure cognitive functions. Scopolamine significantly decreased the spontaneous 
      alternation and step-through latency of C57BL/6J mice in Y-maze test and passive 
      avoidance test, whereas increased the time of mice spent to find the hidden 
      platform in Morris water maze test. Importantly, intraperitoneal administration 
      of P7C3 effectively reversed those Scopolamine-induced cognitive impairments in 
      C57BL/6J mice. Furthermore, P7C3 treatment significantly enhanced the level of 
      brain-derived neurotrophic factor (BDNF) signaling pathway in the cortex and 
      hippocampus, and the usage of selective BDNF signaling inhibitor fully blocked 
      the anti-amnesic effects of P7C3. Therefore, these findings suggest that P7C3 
      could improve the scopolamine-induced learning and memory impairment possibly 
      through activation of BDNF signaling pathway, thereby exhibiting a 
      cognition-enhancing potential.
FAU - Jiang, Bo
AU  - Jiang B
AD  - Department of Pharmacology, Pharmacy College, Nantong University, 19 QiXiu Road, 
      Nantong, 226001, Jiangsu, China. jiangbo78099@ntu.edu.cn.
AD  - Provincial Key Laboratory of Inflammation and Molecular Drug Target, Nantong, 
      Jiangsu, China. jiangbo78099@ntu.edu.cn.
FAU - Song, Lu
AU  - Song L
AD  - Department of Pharmacology, Pharmacy College, Nantong University, 19 QiXiu Road, 
      Nantong, 226001, Jiangsu, China.
AD  - Provincial Key Laboratory of Inflammation and Molecular Drug Target, Nantong, 
      Jiangsu, China.
FAU - Huang, Chao
AU  - Huang C
AD  - Department of Pharmacology, Pharmacy College, Nantong University, 19 QiXiu Road, 
      Nantong, 226001, Jiangsu, China.
AD  - Provincial Key Laboratory of Inflammation and Molecular Drug Target, Nantong, 
      Jiangsu, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Pharmacology, Pharmacy College, Nantong University, 19 QiXiu Road, 
      Nantong, 226001, Jiangsu, China. zhangw@ntu.edu.cn.
AD  - Provincial Key Laboratory of Inflammation and Molecular Drug Target, Nantong, 
      Jiangsu, China. zhangw@ntu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151208
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Muscarinic Antagonists)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (P7C3 compound)
RN  - DL48G20X8X (Scopolamine)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Carbazoles/*pharmacology/therapeutic use
MH  - Cerebral Cortex/drug effects/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Maze Learning
MH  - Memory/*drug effects
MH  - Memory Disorders/chemically induced/*drug therapy/psychology
MH  - Mice, Inbred C57BL
MH  - *Muscarinic Antagonists
MH  - Neuroprotective Agents/*pharmacology/therapeutic use
MH  - *Scopolamine
MH  - Signal Transduction
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Memory
OT  - P7C3
OT  - Scopolamine
OT  - cAMP response element-binding protein
EDAT- 2015/12/10 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/12/10 06:00
PHST- 2015/07/30 00:00 [received]
PHST- 2015/11/20 00:00 [accepted]
PHST- 2015/11/17 00:00 [revised]
PHST- 2015/12/10 06:00 [entrez]
PHST- 2015/12/10 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1007/s11064-015-1783-y [pii]
AID - 10.1007/s11064-015-1783-y [doi]
PST - ppublish
SO  - Neurochem Res. 2016 May;41(5):1010-9. doi: 10.1007/s11064-015-1783-y. Epub 2015 
      Dec 8.