PMID- 26646040 OWN - NLM STAT- MEDLINE DCOM- 20160329 LR - 20151209 IS - 1555-2101 (Electronic) IS - 0160-6689 (Linking) VI - 76 IP - 11 DP - 2015 Nov TI - Frequency and correlates of DSM-5 attenuated psychosis syndrome in a sample of adolescent inpatients with nonpsychotic psychiatric disorders. PG - e1449-58 LID - 10.4088/JCP.14m09435 [doi] AB - OBJECTIVES: DSM-5 conceptualized attenuated psychosis syndrome (APS) as self-contained rather than as a risk syndrome, including it under "Conditions for Further Study," but also as a codable/billable condition in the main section. Since many major mental disorders emerge during adolescence, we assessed the frequency and characteristics of APS in adolescent psychiatric inpatients. METHODS: Consecutively recruited adolescents hospitalized for nonpsychotic disorders (September 2009-May 2013) were divided into APS youth versus non-APS youth, based on the Structured Interview of Prodromal Syndromes (SIPS) and according to DSM-5 criteria, and compared across multiple characteristics. RESULTS: Of 89 adolescents (mean +/- SD age = 15.1 +/- 1.6 years), 21 (23.6%) had APS. Compared to non-APS, APS was associated with more comorbid disorders (2.7 +/- 1.0 vs 2.2 +/- 1.3), major depressive disorder (61.9% vs 27.9%), oppositional defiant disorder/conduct disorder (52.4% vs 25.0%), and personality disorder traits (57.1% vs 7.4%, the only diagnostic category surviving Bonferroni correction). APS youth were more severely ill, having higher SIPS total positive, negative, and general symptoms; Brief Psychiatric Rating Scale total and positive scores; depression and global illness ratings; and lower Global Assessment of Functioning (GAF). Conversely, Young Mania Rating Scale scores, suicidal behavior, prescribed psychotropic medications, and mental disorder awareness were similar between APS and non-APS groups. In multivariable analysis, lowest GAF score in the past year (odds ratio [OR] = 51.15; 95% confidence interval [CI], 2.46-2,439.0) and social isolation (OR = 27.52; 95% CI, 3.36-313.87) were independently associated with APS (r(2) = 0.302, P < .0001). Although psychotic disorders were excluded, 65.2% (APS = 57.1%, non-APS = 67.7%, P = .38) received antipsychotics. CONCLUSION: One in 4 nonpsychotic adolescent inpatients met DSM-5 criteria for APS. APS youth were more impaired, showing a complex entanglement with a broad range of psychiatric symptoms and disorders, including depression, impulse-control, and, especially, emerging personality disorders. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01383915. CI - (c) Copyright 2015 Physicians Postgraduate Press, Inc. FAU - Gerstenberg, Miriam AU - Gerstenberg M AD - University Clinics for Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland. FAU - Hauser, Marta AU - Hauser M FAU - Al-Jadiri, Aseel AU - Al-Jadiri A FAU - Sheridan, Eva M AU - Sheridan EM FAU - Kishimoto, Taishiro AU - Kishimoto T FAU - Borenstein, Yehonatan AU - Borenstein Y FAU - Vernal, Ditte L AU - Vernal DL FAU - David, Lisa AU - David L FAU - Saito, Ema AU - Saito E FAU - Landers, Sara E AU - Landers SE FAU - Carella, Morgan AU - Carella M FAU - Singh, Sukhbir AU - Singh S FAU - Carbon, Maren AU - Carbon M FAU - Jimenez-Fernandez, Sara AU - Jimenez-Fernandez S FAU - Birnbaum, Michael L AU - Birnbaum ML FAU - Auther, Andrea AU - Auther A FAU - Carrion, Ricardo E AU - Carrion RE FAU - Cornblatt, Barbara A AU - Cornblatt BA FAU - Kane, John M AU - Kane JM FAU - Walitza, Susanne AU - Walitza S FAU - Correll, Christoph U AU - Correll CU LA - eng SI - ClinicalTrials.gov/NCT01383915 GR - P30MH090590/MH/NIMH NIH HHS/United States PT - Clinical Trial PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - United States TA - J Clin Psychiatry JT - The Journal of clinical psychiatry JID - 7801243 SB - IM MH - Adolescent MH - Comorbidity MH - *Diagnostic and Statistical Manual of Mental Disorders MH - Female MH - Humans MH - Male MH - Mental Disorders/*epidemiology MH - Personality Disorders/*epidemiology MH - Psychotic Disorders/*epidemiology MH - Severity of Illness Index MH - Syndrome EDAT- 2015/12/10 06:00 MHDA- 2016/03/30 06:00 CRDT- 2015/12/10 06:00 PHST- 2014/08/06 00:00 [received] PHST- 2015/01/20 00:00 [accepted] PHST- 2015/12/10 06:00 [entrez] PHST- 2015/12/10 06:00 [pubmed] PHST- 2016/03/30 06:00 [medline] AID - 10.4088/JCP.14m09435 [doi] PST - ppublish SO - J Clin Psychiatry. 2015 Nov;76(11):e1449-58. doi: 10.4088/JCP.14m09435.