PMID- 26646196
OWN - NLM
STAT- MEDLINE
DCOM- 20170404
LR  - 20170404
IS  - 1442-200X (Electronic)
IS  - 1328-8067 (Linking)
VI  - 58
IP  - 7
DP  - 2016 Jul
TI  - Safety of lipid emulsion in very low-birthweight infants according to cytokine 
      level.
PG  - 556-61
LID - 10.1111/ped.12871 [doi]
AB  - BACKGROUND: The aim of this study was to verify whether lipid emulsion treatment 
      aggravates infection and inflammation in very low-birthweight (VLBW) infants. 
      STUDY DESIGN: Very low-birthweight (<1500 g) infants born at <32 weeks 
      gestational age between October 2013 and October 2014 at Dokkyo Medical 
      University Hospital (Mibu, Tochigi, Japan) were treated with or without i.v. 
      nutrition with a lipid emulsion. Infants were excluded who had congenital 
      abnormalities, could not receive i.v. nutrition because of poor general 
      condition, or on physician decision. Lipid emulsion with purified soybean oil was 
      initiated at 0.5 g/kg/day on postnatal day 1. The dose was increased to 
      1 g/kg/day, and then to 1.5 g/kg/day (maximum dose). Blood tests were performed 
      before (day 1) and after (day 8) initiation of lipid emulsion treatment. 
      Interleukin (IL)-6, IL-8, monocyte chemotactic protein 1 (MCP-1), tumor necrosis 
      factor-alpha (TNF-alpha), C-reactive protein (CRP), total bilirubin (T-Bil), direct 
      bilirubin (D-Bil) and insulin were measured. Changes in respiratory condition, 
      amount of oxygen used, and phototherapy duration were investigated. RESULTS: A 
      total of 17 treated and 15 untreated VLBW infants were enrolled. IL-6, IL-8, 
      MCP-1, TNF-alpha, CRP, T-Bil, D-Bil and insulin on days 1 and 8; respirator or 
      surfactant use; amount of oxygen used; and phototherapy duration were not 
      significantly different between the two groups. CONCLUSIONS: Lipid emulsion 
      treatment did not increase inflammatory cytokine levels or aggravate respiratory 
      disorders. Lipid emulsions, if proven safe, could be used to treat VLBW infants 
      soon after birth, which may prevent extrauterine growth restriction and improve 
      intellectual development prognosis.
CI  - (c) 2015 Japan Pediatric Society.
FAU - Ichikawa, Junko
AU  - Ichikawa J
AD  - Department of Pediatrics, Dokkyo Medical University Hospital, Mibu, Tochigi, 
      Japan.
FAU - Ichikawa, Go
AU  - Ichikawa G
AD  - Department of Pediatrics, Dokkyo Medical University Hospital, Mibu, Tochigi, 
      Japan.
FAU - Tsuboi, Yayoi
AU  - Tsuboi Y
AD  - Department of Pediatrics, Dokkyo Medical University Hospital, Mibu, Tochigi, 
      Japan.
FAU - Kuribayashi, Ryota
AU  - Kuribayashi R
AD  - Department of Pediatrics, Dokkyo Medical University Hospital, Mibu, Tochigi, 
      Japan.
FAU - Watabe, Yoshiyuki
AU  - Watabe Y
AD  - Department of Pediatrics, Dokkyo Medical University Hospital, Mibu, Tochigi, 
      Japan.
FAU - Sairenchi, Toshimi
AU  - Sairenchi T
AD  - Department of Public Health, Dokkyo Medical University School of Medicine, Mibu, 
      Japan.
FAU - Suzumura, Hiroshi
AU  - Suzumura H
AD  - Department of Pediatrics, Dokkyo Medical University Hospital, Mibu, Tochigi, 
      Japan.
FAU - Arisaka, Osamu
AU  - Arisaka O
AD  - Department of Pediatrics, Dokkyo Medical University Hospital, Mibu, Tochigi, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20160204
PL  - Australia
TA  - Pediatr Int
JT  - Pediatrics international : official journal of the Japan Pediatric Society
JID - 100886002
RN  - 0 (Cytokines)
RN  - 0 (Fat Emulsions, Intravenous)
SB  - IM
MH  - Cytokines/*blood
MH  - Fat Emulsions, Intravenous/*administration & dosage
MH  - Female
MH  - Follow-Up Studies
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Infant, Premature, Diseases/blood/*drug therapy
MH  - *Infant, Very Low Birth Weight
MH  - Male
MH  - Parenteral Nutrition/*methods
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - cytokine
OT  - lipid emulsion
OT  - nutrition
OT  - postnatal growth restriction
OT  - very low-birthweight
EDAT- 2015/12/10 06:00
MHDA- 2017/04/05 06:00
CRDT- 2015/12/10 06:00
PHST- 2015/06/30 00:00 [received]
PHST- 2015/11/14 00:00 [revised]
PHST- 2015/12/01 00:00 [accepted]
PHST- 2015/12/10 06:00 [entrez]
PHST- 2015/12/10 06:00 [pubmed]
PHST- 2017/04/05 06:00 [medline]
AID - 10.1111/ped.12871 [doi]
PST - ppublish
SO  - Pediatr Int. 2016 Jul;58(7):556-61. doi: 10.1111/ped.12871. Epub 2016 Feb 4.