PMID- 26647286
OWN - NLM
STAT- MEDLINE
DCOM- 20170516
LR  - 20181202
IS  - 1478-6427 (Electronic)
IS  - 1478-6419 (Linking)
VI  - 30
IP  - 18
DP  - 2016 Sep
TI  - A new phenolic derivative with soluble epoxide hydrolase and nuclear 
      factor-kappaB inhibitory activity from the aqueous extract of Acacia catechu.
PG  - 2085-92
LID - 10.1080/14786419.2015.1114937 [doi]
AB  - One novel phenolic compound, 
      (4S,5R)-4-(3,4-dihydroxyphenyl)-5-(3-oxobutyl)dihydrofuran-2(3H)-one (1), as well 
      as 12 known compounds (2-13) was obtained from the aqueous extract of Acacia 
      catechu and their chemical structures were determined by spectroscopic analysis. 
      Compounds 8 and 9 exhibited significant soluble epoxide hydrolase (sEH) 
      inhibitory activities with IC50 values of 26.6 +/- 0.5 and 24.4 +/- 5.6 muM, 
      respectively. Compounds 7-10 showed significant inhibitory effects on 
      TNFalpha-induced nuclear factor kappa B (NF-kappaB) transcriptional activity in a 
      dose-dependent manner, with IC50 values ranging from 11.15 to 19.45 muM.
FAU - Sun, Ya Nan
AU  - Sun YN
AD  - a College of Pharmacy , Chungnam National University , Daejeon , Korea.
FAU - Li, Wei
AU  - Li W
AD  - b School of Biotechnology , Yeungnam University , Gyeongsan , Korea.
FAU - Song, Seok Bean
AU  - Song SB
AD  - c Gyeongbuk Institute for Bio-industry (GIB) , Andong City , Korea.
FAU - Yan, Xi Tao
AU  - Yan XT
AD  - d Shaanxi Key Laboratory of Natural Products & Chemical Biology , College of 
      Science, Northwest A & F University , Yangling , China.
FAU - Zhao, Yan
AU  - Zhao Y
AD  - a College of Pharmacy , Chungnam National University , Daejeon , Korea.
FAU - Jo, A Reum
AU  - Jo AR
AD  - a College of Pharmacy , Chungnam National University , Daejeon , Korea.
FAU - Kang, Jong Seong
AU  - Kang JS
AD  - a College of Pharmacy , Chungnam National University , Daejeon , Korea.
FAU - Young Ho, Kim
AU  - Young Ho K
AD  - a College of Pharmacy , Chungnam National University , Daejeon , Korea.
LA  - eng
PT  - Journal Article
DEP - 20151208
PL  - England
TA  - Nat Prod Res
JT  - Natural product research
JID - 101167924
RN  - 0 ((4S,5R)-4-(3,4-dihydroxyphenyl)-5-(3-oxobutyl)dihydrofuran-2(3H)-one)
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (NF-kappa B)
RN  - 0 (Phenols)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.3.2.- (Epoxide Hydrolases)
SB  - IM
MH  - Acacia/*chemistry
MH  - Antineoplastic Agents, Phytogenic/pharmacology
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - China
MH  - Enzyme Inhibitors/*pharmacology
MH  - Epoxide Hydrolases/*antagonists & inhibitors
MH  - Humans
MH  - Magnetic Resonance Spectroscopy
MH  - NF-kappa B/*antagonists & inhibitors
MH  - Phenols/chemistry/*pharmacology
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Spectrometry, Mass, Electrospray Ionization
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors
OTO - NOTNLM
OT  - Acacia catechu
OT  - Leguminosae
OT  - NF-kappa B
OT  - soluble epoxide hydrolase (sEH)
EDAT- 2015/12/10 06:00
MHDA- 2017/05/17 06:00
CRDT- 2015/12/10 06:00
PHST- 2015/12/10 06:00 [entrez]
PHST- 2015/12/10 06:00 [pubmed]
PHST- 2017/05/17 06:00 [medline]
AID - 10.1080/14786419.2015.1114937 [doi]
PST - ppublish
SO  - Nat Prod Res. 2016 Sep;30(18):2085-92. doi: 10.1080/14786419.2015.1114937. Epub 
      2015 Dec 8.