PMID- 26647542
OWN - NLM
STAT- MEDLINE
DCOM- 20160621
LR  - 20190221
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 29
IP  - 17
DP  - 2015 Sep
TI  - [Subtype analysis and clinical significance of HPV infection in laryngeal 
      squamous cell carcinoma and precancerous lesions].
PG  - 1549-52
AB  - OBJECTIVE: To investigate the correlation of laryngeal squamous cell carcinoma 
      (LSCC) and precancerous lesion with HPV infection subtypes and possible clinical 
      relationship. METHOD: Eighty-three cases in paraffin embedded tissues were 
      detected with thirty seven HPV subtypes by flow-through hybridization and gene 
      chip (HybriMax), including 31 cases of laryngeal squamous cell carcinoma, 52 
      cases of precancerous lesions (29 cases of vocal cord leukoplakia and 23 cases of 
      laryngeal papilloma), and 36 cases of vocal cord polyp as normal vocal mucosa 
      were used as control. RESULT: The total positive rate of HPV was 19.4% in the 
      group of laryngeal squamous cell carcinoma (6/31), 0 in vocal cord leukoplakia, 
      65.2% in laryngeal papilloma (15/23), and the control group were all negative, 
      HPV virus subtype of HPV-positive laryngeal squamous cell carcinoma were all 
      high-risk HPV16; and there were 6 HPV virus subtypes in laryngeal papilloma (8: 
      HPV6,4: HPV52, 1: HPV11, 1: HPV18, 2: HPV45, 3: HPV16), individual mixing two or 
      more subtypes infection. HPV infection of laryngeal squamous cell carcinoma and 
      precancerous lesions has no statistically significant difference according to 
      gender, high low-risk subtypes. CONCLUSION: HPV infection related to laryngeal 
      squamous cell carcinoma and precancerous lesions, but no significant correlation 
      with the subtype distribution of high and low risk; HPV detection is making 
      positive sense to clinical diagnosis of laryngeal carcinoma and precancerous 
      lesions as well as the development of specific HPV subtype vaccine.
FAU - Guan, Linlin
AU  - Guan L
FAU - Sun, Na
AU  - Sun N
FAU - Sun, Guangbin
AU  - Sun G
FAU - Fang, Qin
AU  - Fang Q
FAU - Meng, Yang
AU  - Meng Y
FAU - Zhao, Xiaoyan
AU  - Zhao X
FAU - Meng, Lingchao
AU  - Meng L
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
SB  - IM
MH  - Carcinoma, Squamous Cell/complications/*virology
MH  - Genotype
MH  - Head and Neck Neoplasms/complications/*virology
MH  - Human papillomavirus 11
MH  - Humans
MH  - Laryngeal Neoplasms/complications/*virology
MH  - Papilloma/complications/virology
MH  - Papillomaviridae/*classification
MH  - Papillomavirus Infections/*complications/virology
MH  - Precancerous Conditions
MH  - Squamous Cell Carcinoma of Head and Neck
EDAT- 2015/12/10 06:00
MHDA- 2016/06/22 06:00
CRDT- 2015/12/10 06:00
PHST- 2015/12/10 06:00 [entrez]
PHST- 2015/12/10 06:00 [pubmed]
PHST- 2016/06/22 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Sep;29(17):1549-52.