PMID- 26647900
OWN - NLM
STAT- MEDLINE
DCOM- 20160722
LR  - 20181202
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Linking)
VI  - 24
IP  - 1
DP  - 2016 Jan
TI  - Fat depot-specific expression of HOXC9 and HOXC10 may contribute to adverse fat 
      distribution and related metabolic traits.
PG  - 51-9
LID - 10.1002/oby.21317 [doi]
AB  - OBJECTIVE: Independent previous studies in both rodents and humans suggest a role 
      of developmental genes in the origin of obesity and body fat distribution. Here, 
      the hypothesis that human adipose tissue (AT) expression of the developmental 
      genes homeobox transcription factors C9 (HOXC9) and C10 (HOXC10) is fat 
      depot-specific and related to obesity-related traits was tested. METHODS: In 636 
      individuals, HOXC9 and HOXC10 mRNA expression was investigated in paired 
      abdominal subcutaneous (SC) and omental AT samples in relation to a wide range of 
      age, BMI, fat distribution, and metabolic parameters and in subfractions of 
      isolated adipocytes and cells of the stromal vascular fraction (SVF). RESULTS: 
      HOXC9 and HOXC10 mRNA expression is significantly higher in SC compared to 
      omental AT. HOXC9 and HOXC10 mRNA expression significantly correlates with body 
      fat mass, even after adjustment for age and gender. In smaller subgroups 
      (depending on the availability of data), fat depot-related significant gender- 
      and BMI-independent associations between HOXC9 and HOXC10 gene expression and 
      parameters of glucose metabolism and AT biology were found (e.g., adipocyte 
      size). CONCLUSIONS: Taken together, these data suggest that HOXC9 and HOXC10 may 
      play an important role in the development of obesity, adverse fat distribution, 
      and subsequent alterations in whole-body metabolism and AT function.
CI  - (c) 2015 The Obesity Society.
FAU - Brune, Jakob E
AU  - Brune JE
AD  - IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.
FAU - Kern, Matthias
AU  - Kern M
AD  - Department of Medicine, University of Leipzig, Leipzig, Germany.
FAU - Kunath, Anne
AU  - Kunath A
AD  - Department of Medicine, University of Leipzig, Leipzig, Germany.
AD  - German Center for Diabetes Research (DZD), Leipzig, Germany.
FAU - Flehmig, Gesine
AU  - Flehmig G
AD  - Department of Medicine, University of Leipzig, Leipzig, Germany.
AD  - German Center for Diabetes Research (DZD), Leipzig, Germany.
FAU - Schon, Michael R
AU  - Schon MR
AD  - Stadtisches Klinikum Karlsruhe, Clinic of Visceral Surgery, Karlsruhe, Germany.
FAU - Lohmann, Tobias
AU  - Lohmann T
AD  - Municipal Clinic Dresden-Neustadt, Dresden, Germany.
FAU - Dressler, Miriam
AU  - Dressler M
AD  - Municipal Clinic Dresden-Neustadt, Dresden, Germany.
FAU - Dietrich, Arne
AU  - Dietrich A
AD  - IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.
AD  - Department of Surgery, University of Leipzig, Leipzig, Germany.
FAU - Fasshauer, Mathias
AU  - Fasshauer M
AD  - Department of Medicine, University of Leipzig, Leipzig, Germany.
FAU - Kovacs, Peter
AU  - Kovacs P
AD  - Department of Medicine, University of Leipzig, Leipzig, Germany.
FAU - Stumvoll, Michael
AU  - Stumvoll M
AD  - Department of Medicine, University of Leipzig, Leipzig, Germany.
FAU - Bluher, Matthias
AU  - Bluher M
AD  - Department of Medicine, University of Leipzig, Leipzig, Germany.
FAU - Kloting, Nora
AU  - Kloting N
AD  - IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151209
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (HOXC10 protein, human)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Hoxc9 protein, human)
SB  - IM
MH  - Abdomen
MH  - Adipocytes/metabolism
MH  - Adipose Tissue/*metabolism
MH  - Adult
MH  - *Body Fat Distribution
MH  - Female
MH  - Gene Expression
MH  - Homeodomain Proteins/genetics/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/*genetics/*metabolism
MH  - Omentum/metabolism
MH  - Phenotype
EDAT- 2015/12/10 06:00
MHDA- 2016/07/23 06:00
CRDT- 2015/12/10 06:00
PHST- 2015/05/29 00:00 [received]
PHST- 2015/07/08 00:00 [revised]
PHST- 2015/07/24 00:00 [accepted]
PHST- 2015/12/10 06:00 [entrez]
PHST- 2015/12/10 06:00 [pubmed]
PHST- 2016/07/23 06:00 [medline]
AID - 10.1002/oby.21317 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2016 Jan;24(1):51-9. doi: 10.1002/oby.21317. Epub 2015 
      Dec 9.