PMID- 26648854
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151209
LR  - 20200929
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 9
DP  - 2015
TI  - Interaction does Count: A Cross-Fostering Study on Transgenerational Effects of 
      Pre-reproductive Maternal Enrichment.
PG  - 320
LID - 10.3389/fnbeh.2015.00320 [doi]
LID - 320
AB  - Pre-reproductive environmental enrichment of female rats influences sensorimotor 
      development and spatial behavior of the offspring, possibly through the changed 
      maternal nurturing. Nevertheless, maternal care could be not the solely 
      responsible for changing offspring developmental trajectories. To disentangle the 
      specific contribution to the transgenerational inheritance of pre- and post-natal 
      factors, a cross-fostering study was performed. Female rats were reared in an 
      enriched environment from weaning to sexual maturity, while control female rats 
      were reared under standard conditions. Following mating with standard-reared 
      males, all females were housed individually. Immediately after delivery, in- or 
      cross-fostering manipulations were performed so that any foster dams received 
      pups born to another dam of the same (in-fostering) or the opposite 
      (cross-fostering) pre-reproductive rearing condition. In lactating dams maternal 
      care and nesting activities were assessed, while in their male pups spatial 
      abilities were assessed through Morris Water Maze (MWM) test at post-natal day 
      45. Moreover, the expression of Brain-Derived-Neurotrophic-Factor (BDNF) was 
      evaluated in the hippocampus and frontal cortex of dams and pups at weaning. 
      Pre-reproductive maternal environmental enrichment, followed by adoption 
      procedures, loosened its potential in modifying maternal care and offspring 
      developmental trajectories, as indicated by the lack of differences between 
      in-fostered groups of dams and pups. In addition, enriched dams rearing standard 
      pups showed the least complex maternal repertoire (the highest sniffing duration 
      and the lowest nest quality), and their pups showed a reduced spatial learning in 
      the MWM. Nevertheless, pre-reproductive maternal enrichment kept influencing 
      neurotrophic pattern, with enriched dams expressing increased frontal BDNF levels 
      (regardless of the kind of fostered pups), and their offspring expressing 
      increased hippocampal BDNF levels. The present findings enlighten the crucial 
      importance of the early mother-pups interactions in influencing maternal care and 
      offspring phenotype, with the enriched dam-standard pups couple resulting in the 
      most maladaptive encounter. Our study thus sustains that the bidirectional 
      interactions between mother and pups are able to deeply shape offspring 
      phenotype.
FAU - Caporali, Paola
AU  - Caporali P
AD  - Department of Psychology, Faculty of Medicine and Psychology, University 
      "Sapienza" of Rome Rome, Italy.
FAU - Cutuli, Debora
AU  - Cutuli D
AD  - Department of Psychology, Faculty of Medicine and Psychology, University 
      "Sapienza" of Rome Rome, Italy ; I.R.C.C.S., Santa Lucia Foundation Rome, Italy.
FAU - Gelfo, Francesca
AU  - Gelfo F
AD  - I.R.C.C.S., Santa Lucia Foundation Rome, Italy ; Department of Systemic Medicine, 
      University of Rome "Tor Vergata" Rome, Italy.
FAU - Laricchiuta, Daniela
AU  - Laricchiuta D
AD  - Department of Psychology, Faculty of Medicine and Psychology, University 
      "Sapienza" of Rome Rome, Italy ; I.R.C.C.S., Santa Lucia Foundation Rome, Italy.
FAU - Foti, Francesca
AU  - Foti F
AD  - Department of Psychology, Faculty of Medicine and Psychology, University 
      "Sapienza" of Rome Rome, Italy ; I.R.C.C.S., Santa Lucia Foundation Rome, Italy.
FAU - De Bartolo, Paola
AU  - De Bartolo P
AD  - I.R.C.C.S., Santa Lucia Foundation Rome, Italy ; Department of Sociological and 
      Psychopedagogical Studies, University "Guglielmo Marconi" of Rome Rome, Italy.
FAU - Angelucci, Francesco
AU  - Angelucci F
AD  - I.R.C.C.S., Santa Lucia Foundation Rome, Italy.
FAU - Petrosini, Laura
AU  - Petrosini L
AD  - Department of Psychology, Faculty of Medicine and Psychology, University 
      "Sapienza" of Rome Rome, Italy ; I.R.C.C.S., Santa Lucia Foundation Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20151201
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC4665747
OTO - NOTNLM
OT  - BDNF
OT  - cognition
OT  - cross-fostering
OT  - environmental enrichment
OT  - maternal care
OT  - rats
EDAT- 2015/12/10 06:00
MHDA- 2015/12/10 06:01
PMCR- 2015/01/01
CRDT- 2015/12/10 06:00
PHST- 2015/10/07 00:00 [received]
PHST- 2015/11/09 00:00 [accepted]
PHST- 2015/12/10 06:00 [entrez]
PHST- 2015/12/10 06:00 [pubmed]
PHST- 2015/12/10 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2015.00320 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2015 Dec 1;9:320. doi: 10.3389/fnbeh.2015.00320. 
      eCollection 2015.