PMID- 26650242
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1475-2700 (Electronic)
IS  - 0954-4224 (Linking)
VI  - 28
IP  - 2
DP  - 2015 Dec
TI  - Obesity and diabetes: the link between adipose tissue dysfunction and glucose 
      homeostasis.
PG  - 121-132
AB  - Obesity and type 2 diabetes mellitus (T2DM) epidemics, which have already spread, 
      imply the possibility of both conditions being closely related. Thus, the goal of 
      the present review was to draw a parallel between obesity, adipose tissue (AT) 
      changes, and T2DM development. To this end, a search was conducted in PubMed, 
      MEDLINE and SciELO databases, using the following key words and their 
      combinations: obesity; diabetes; insulin resistance; diet; weight loss; adipocin; 
      inflammation markers; and interleukins. Based on a literature review, AT 
      dysfunction observed in obesity is characterised by adipocyte hypertrophy, 
      macrophage infiltration, impaired insulin signalling and insulin resistance. In 
      addition, there is release of inflammatory adipokines and an excessive amount of 
      NEFA promoting ectopic fat deposition and lipotoxicity in muscle, liver and 
      pancreas. Recent evidence supports the hypothesis that the conception of AT as a 
      passive energy storage organ should be replaced by a dynamic endocrine organ, 
      which regulates metabolism through a complex adipocyte communication with the 
      surrounding microenvironment. The present review demonstrates how glucose 
      homeostasis is changed by AT dysfunction. A better understanding of this 
      relationship enables performing nutritional intervention strategies with the goal 
      of preventing T2DM.
FAU - Abranches, Monise Viana
AU  - Abranches MV
AD  - 1Instituto de Ciencias Biologicas e da Saude,Universidade Federal de Vicosa 
      Campus de Rio Paranaiba,Rodovia MG-230 - Km 7,Rio Paranaiba,MG, 38810-000,Brazil.
FAU - Oliveira, Fernanda Cristina Esteves de
AU  - Oliveira FC
AD  - 2Departamento de Enfermagem, Faculdade de Ciencias Sociais Aplicadas de 
      Sinop,Sinop,MT, 78550-000,Brazil.
FAU - Conceicao, Lisiane Lopes da
AU  - Conceicao LL
AD  - 3Departamento de Nutricao e Saude,Universidade Federal de Vicosa,Campus 
      Universitario,Edificio Centro de Ciencias Biologicas II,s/n,Vicosa,MG, 
      36571-900,Brazil.
FAU - Peluzio, Maria do Carmo Gouveia
AU  - Peluzio MD
AD  - 3Departamento de Nutricao e Saude,Universidade Federal de Vicosa,Campus 
      Universitario,Edificio Centro de Ciencias Biologicas II,s/n,Vicosa,MG, 
      36571-900,Brazil.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nutr Res Rev
JT  - Nutrition research reviews
JID - 9113797
OTO - NOTNLM
OT  - AT adipose tissue
OT  - LPL lipoprotein lipase
OT  - MCP-1 monocyte chemotactic protein-1
OT  - PAI-1 plasminogen activator inhibitor-1
OT  - T2DM type 2 diabetes mellitus
OT  - TZD thiazolidinediones
OT  - Fat deposition
OT  - Inflammation
OT  - Obesity
OT  - Type 2 diabetes mellitus
EDAT- 2015/12/10 06:00
MHDA- 2015/12/10 06:00
CRDT- 2015/12/10 06:00
PHST- 2015/12/10 06:00 [entrez]
PHST- 2015/12/10 06:00 [pubmed]
PHST- 2015/12/10 06:00 [medline]
AID - S0954422415000098 [pii]
AID - 10.1017/S0954422415000098 [doi]
PST - ppublish
SO  - Nutr Res Rev. 2015 Dec;28(2):121-132. doi: 10.1017/S0954422415000098.