PMID- 26653711
OWN - NLM
STAT- MEDLINE
DCOM- 20160725
LR  - 20191218
IS  - 1465-2099 (Electronic)
IS  - 0022-1317 (Linking)
VI  - 97
IP  - 3
DP  - 2016 Mar
TI  - Elevated plasma-soluble CD16 levels in porcine reproductive and respiratory 
      syndrome virus-infected pigs: correlation with ADAM17-mediated shedding.
PG  - 632-638
LID - 10.1099/jgv.0.000368 [doi]
AB  - Soluble CD16 (sCD16) is closely correlated with chronic diseases in humans. Here, 
      plasma sCD16 levels in pigs were increased by infection with porcine reproductive 
      and respiratory syndrome virus (PRRSV) but not with porcine epidemic diarrhea 
      virus, porcine circovirus type 2 and pseudorabies virus. Of interest, PRRSV 
      attached to blood neutrophils and reduced surface CD16 expression on neutrophils. 
      In vitro data confirmed that PRRSV caused CD16 shedding in neutrophils. Further 
      analyses revealed that ADAM17 was involved in porcine CD16 shedding. Thus, our 
      findings suggest that increase in sCD16 levels may be an indicator of PRRSV 
      infection.
FAU - Gu, Weihong
AU  - Gu W
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.
FAU - Guo, Longjun
AU  - Guo L
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.
FAU - Li, Ren
AU  - Li R
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.
FAU - Niu, Junwei
AU  - Niu J
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.
FAU - Luo, Xiaolei
AU  - Luo X
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.
FAU - Xu, Yunfei
AU  - Xu Y
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.
FAU - Tian, Zhijun
AU  - Tian Z
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.
FAU - Feng, Li
AU  - Feng L
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.
FAU - Wang, Yue
AU  - Wang Y
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151210
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - 0 (Receptors, IgG)
RN  - EC 3.4.24.- (ADAM Proteins)
RN  - EC 3.4.24.86 (ADAM17 Protein)
RN  - EC 3.4.24.86 (ADAM17 protein, human)
SB  - IM
MH  - ADAM Proteins/genetics/*metabolism
MH  - ADAM17 Protein
MH  - Animals
MH  - Host-Pathogen Interactions
MH  - Neutrophils/metabolism/virology
MH  - Porcine Reproductive and Respiratory Syndrome/blood/*enzymology/genetics/virology
MH  - Porcine respiratory and reproductive syndrome virus/genetics/*physiology
MH  - Receptors, IgG/*blood/genetics
MH  - Sus scrofa
MH  - Swine
EDAT- 2015/12/15 06:00
MHDA- 2016/07/28 06:00
CRDT- 2015/12/15 06:00
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2016/07/28 06:00 [medline]
AID - 10.1099/jgv.0.000368 [doi]
PST - ppublish
SO  - J Gen Virol. 2016 Mar;97(3):632-638. doi: 10.1099/jgv.0.000368. Epub 2015 Dec 10.