PMID- 26655130
OWN - NLM
STAT- MEDLINE
DCOM- 20161026
LR  - 20191210
IS  - 1998-4049 (Electronic)
IS  - 1319-3767 (Print)
IS  - 1319-3767 (Linking)
VI  - 21
IP  - 6
DP  - 2015 Nov-Dec
TI  - Rapid fecal calprotectin testing to assess for endoscopic disease activity in 
      inflammatory bowel disease: A diagnostic cohort study.
PG  - 360-6
LID - 10.4103/1319-3767.170948 [doi]
AB  - BACKGROUND AND AIM: With increasing numbers of patients diagnosed with 
      inflammatory bowel disease (IBD), it is important to identify noninvasive methods 
      of detecting disease activity. The aim of this study is to examine the diagnostic 
      accuracy of fecal rapid calprotectin (FC) testing in the detection of 
      endoscopically active IBD. PATIENTS AND METHODS: All consecutive patients 
      presenting to outpatient clinics with lower gastrointestinal symptoms were 
      prospectively recruited. Patients provided FC samples. Sensitivity (Sn), 
      specificity (Sp), positive predictive value (PPV), and negative predictive value 
      (NPV) for FC were calculated. Receiver-operator characteristics (ROC) curve was 
      used to identify the ideal FC cutoff that predicts endoscopic disease activity. 
      Correlation between FC and endoscopic disease activity, disease location, and 
      C-reactive protein (CRP) levels were measured. RESULTS: One hundred and 
      twenty-six patients, of whom 52% were females, were included in the final 
      analysis with a mean age of 44.4 +/- 16.7 years. Comparing FC to endoscopic 
      findings, the following results were calculated: A cutoff point of 100 mug/g 
      showed Sn = 83%, Sp = 67%, PPV = 65%, and NPV = 85%; and 200 mug/g showed Sn = 
      66%, Sp = 82%, PPV = 73%, and NPV = 77%. Based on ROC curve, the best FC cutoff 
      point to predict endoscopic disease activity was 140 mug/g. Using this reference, 
      FC levels strongly correlated with colorectal, ileocolonic, and ileal disease and 
      predicted endoscopic activity. CONCLUSIONS: FC is an accurate test when used as 
      an initial screening tool for patients suspected of having active IBD. Given its 
      noninvasive nature, it may prove to reduce the need for colonoscopy and be an 
      added tool in the management of IBD.
FAU - Kwapisz, Lukasz
AU  - Kwapisz L
FAU - Mosli, Mahmoud
AU  - Mosli M
AD  - Department of Medicine, London Health Sciences Centre, University of Western 
      Ontario, London, Ontario; Department of Medicine, King Abdulaziz University, 
      Jeddah, Kingdom of Saudi Arabia, .
FAU - Chande, Nilesh
AU  - Chande N
FAU - Yan, Brian
AU  - Yan B
FAU - Beaton, Melanie
AU  - Beaton M
FAU - Micsko, Jessica
AU  - Micsko J
FAU - Mennill, Pauline W
AU  - Mennill PW
FAU - Barnett, William
AU  - Barnett W
FAU - Bax, Kevin
AU  - Bax K
FAU - Ponich, Terry
AU  - Ponich T
FAU - Howard, John
AU  - Howard J
FAU - Tirolese, Anthony
AU  - Tirolese A
FAU - Lannigan, Robert
AU  - Lannigan R
FAU - Gregor, James
AU  - Gregor J
LA  - eng
PT  - Journal Article
PL  - India
TA  - Saudi J Gastroenterol
JT  - Saudi journal of gastroenterology : official journal of the Saudi 
      Gastroenterology Association
JID - 9516979
RN  - 0 (Biomarkers)
RN  - 0 (Leukocyte L1 Antigen Complex)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Biomarkers/analysis
MH  - C-Reactive Protein/metabolism
MH  - Cohort Studies
MH  - Colitis, Ulcerative/diagnosis/metabolism
MH  - Colonoscopy
MH  - Crohn Disease/diagnosis/metabolism
MH  - Endoscopy, Digestive System/methods
MH  - Feces/chemistry
MH  - Female
MH  - Humans
MH  - Inflammatory Bowel Diseases/*diagnosis/*metabolism
MH  - Leukocyte L1 Antigen Complex/analysis/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Point-of-Care Systems
MH  - Predictive Value of Tests
MH  - Severity of Illness Index
PMC - PMC4707803
EDAT- 2015/12/15 06:00
MHDA- 2016/10/27 06:00
PMCR- 2015/11/01
CRDT- 2015/12/15 06:00
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2016/10/27 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - SaudiJGastroenterol_2015_21_6_360_170948 [pii]
AID - SJG-21-360 [pii]
AID - 10.4103/1319-3767.170948 [doi]
PST - ppublish
SO  - Saudi J Gastroenterol. 2015 Nov-Dec;21(6):360-6. doi: 10.4103/1319-3767.170948.