PMID- 26655481
OWN - NLM
STAT- MEDLINE
DCOM- 20160826
LR  - 20221207
IS  - 1536-4798 (Electronic)
IS  - 0277-3740 (Linking)
VI  - 35
IP  - 2
DP  - 2016 Feb
TI  - Analysis of Ocular Manifestation and Genetic Association of Allopurinol-Induced 
      Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in South Korea.
PG  - 199-204
LID - 10.1097/ICO.0000000000000708 [doi]
AB  - PURPOSE: To describe the clinical characteristics and genetic background of 
      allopurinol-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis 
      (TEN) in South Korea. METHODS: This is a prospective, noncomparative case series. 
      Visual acuity, detailed medical history, ocular findings, and systemic 
      manifestations of 5 patients (10 eyes) with allopurinol-induced SJS/TEN were 
      recorded. The acute ocular involvement score and the chronic ocular manifestation 
      score were graded on scales of 0-3 and 0-39, respectively, based on severity. 
      Human leukocyte antigen (HLA) genotyping was also performed during the 
      hospitalization. RESULTS: Three patients were diagnosed with SJS, and 2 with TEN. 
      Mild ocular involvement with only conjunctival hyperemia (acute ocular 
      involvement score </= 1) was present in all 10 eyes during the acute stage. 
      Patients were treated with systemic steroids and topical antibiotics, steroids, 
      and preservative-free artificial tears, with rinsing of the ocular surface, in 
      the acute stages of SJS/TEN. In the final follow-up, none of the patients had 
      developed severe chronic ocular complications (chronic ocular manifestation score 
      </= 8), including keratinization, corneal conjunctivalization, mucocutaneous 
      junction involvement, or symblepharon. One patient developed bilateral persistent 
      epithelial defects 3 months after the disease onset, which healed after 
      conservative treatment, leaving a bilateral central corneal haze. HLA genotyping 
      showed that 4 of the 5 patients (80%) were positive for HLA-B*58:01. CONCLUSIONS: 
      Allopurinol-induced SJS/TEN might not cause serious acute or chronic 
      complications of the ocular surface. In addition, our HLA genotyping results are 
      consistent with previous studies reporting a strong association between 
      HLA-B*58:01 and allopurinol-induced SJS/TEN among Koreans.
FAU - Lee, Hyo Seok
AU  - Lee HS
AD  - *Department of Ophthalmology, Chonnam National University Medical School and 
      Hospital, Gwangju, South Korea; Departments of daggerFrontier Medical Science and 
      Technology for Ophthalmology, and double daggerOphthalmology, Kyoto Prefectural University of 
      Medicine, Kyoto, Japan;  section signDepartment of Ophthalmology, Seoul National University 
      College of Medicine, Seoul, South Korea; and  paragraph signDepartment of Ophthalmology, 
      Institute of Vision Research, Yonsei University College of Medicine, Seoul, South 
      Korea.
FAU - Ueta, Mayumi
AU  - Ueta M
FAU - Kim, Mee Kum
AU  - Kim MK
FAU - Seo, Kyoung Yul
AU  - Seo KY
FAU - Sotozono, Chie
AU  - Sotozono C
FAU - Kinoshita, Shigeru
AU  - Kinoshita S
FAU - Yoon, Kyung Chul
AU  - Yoon KC
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cornea
JT  - Cornea
JID - 8216186
RN  - 0 (Glucocorticoids)
RN  - 0 (Gout Suppressants)
RN  - 0 (HLA Antigens)
RN  - 63CZ7GJN5I (Allopurinol)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Aged
MH  - Allopurinol/*adverse effects
MH  - Asian People/ethnology
MH  - Conjunctival Diseases/*chemically induced/drug therapy/ethnology/*genetics
MH  - Drug Eruptions/drug therapy/ethnology/etiology/*genetics
MH  - Female
MH  - Genotype
MH  - Genotyping Techniques
MH  - Glucocorticoids/therapeutic use
MH  - Gout Suppressants/*adverse effects
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Prednisolone/therapeutic use
MH  - Prospective Studies
MH  - Republic of Korea/epidemiology
MH  - Stevens-Johnson Syndrome/drug therapy/ethnology/etiology/*genetics
EDAT- 2015/12/15 06:00
MHDA- 2016/08/27 06:00
CRDT- 2015/12/15 06:00
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2016/08/27 06:00 [medline]
AID - 10.1097/ICO.0000000000000708 [doi]
PST - ppublish
SO  - Cornea. 2016 Feb;35(2):199-204. doi: 10.1097/ICO.0000000000000708.