PMID- 26656344
OWN - NLM
STAT- MEDLINE
DCOM- 20160420
LR  - 20221207
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 94
IP  - 49
DP  - 2015 Dec
TI  - Functional Outcome After Lower Limb Amputation: Is Hyperhomocysteinemia a 
      Predictive Factor?: An Observational Study.
PG  - e2167
LID - 10.1097/MD.0000000000002167 [doi]
LID - e2167
AB  - Lower limb amputation (LLA) is the drastic stage of peripheral arterial disease 
      (PAD) where the hyperhomocysteinemia (H-HCY) seems to be a risk factor. 
      Surprisingly, in literature the levels and the role of homocysteinemia (HCY) in 
      persons with LLA are understudied. This study aims to investigate the level of 
      HCY and its correlation with the functional outcomes after LLA.A case-control 
      study to analyze HCY levels in amputees admitted in a rehabilitation hospital 
      during an investigation period of 1.5 years. Barthel Index was used to assess the 
      functional outcome.We enrolled 91 dysvascular amputees and 44 amputees for other 
      reasons than PAD (controls). The mean level of HCY was found higher in 
      dysvascular amputees (15.2 +/- 7.5) compared to controls (11.0 +/- 5.0, P < 0.0001) 
      with a risk related ratio of 4.78. Normal Gaussian distribution of HCY was 
      observed in controls, whereas in dysvascular amputees the data follow a double 
      Gaussian distribution. Finally, a significant negative correlation was found 
      between HCY and the effectiveness of rehabilitation (R = -0.37, P = 0.001) only 
      in dysvascular amputees.Dysvascular amputees had a level of HCY significantly 
      higher than amputees without PAD. H-HCY seems to influence the functional 
      outcomes of the rehabilitative treatment only in LLA due to PAD.
FAU - Brunelli, Stefano
AU  - Brunelli S
AD  - From the Santa Lucia Foundation, Scientific Institute for Research, 
      Hospitalization and Health Care, Rome, Italy.
FAU - Fusco, Augusto
AU  - Fusco A
FAU - Iosa, Marco
AU  - Iosa M
FAU - Ricciardi, Elena
AU  - Ricciardi E
FAU - Traballesi, Marco
AU  - Traballesi M
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - Homocysteinemia
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Amputation, Surgical/*rehabilitation
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/*epidemiology
MH  - *Lower Extremity
MH  - Male
MH  - Middle Aged
MH  - Peripheral Arterial Disease/*epidemiology
MH  - Risk Factors
MH  - Time Factors
PMC - PMC5008489
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2015/12/15 06:00
MHDA- 2016/04/21 06:00
PMCR- 2015/12/11
CRDT- 2015/12/15 06:00
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2016/04/21 06:00 [medline]
PHST- 2015/12/11 00:00 [pmc-release]
AID - 00005792-201512080-00024 [pii]
AID - 10.1097/MD.0000000000002167 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2015 Dec;94(49):e2167. doi: 10.1097/MD.0000000000002167.