PMID- 26656537
OWN - NLM
STAT- MEDLINE
DCOM- 20161014
LR  - 20220318
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 178
DP  - 2016 Feb 3
TI  - The renal protective effects of Anoectochilus roxburghii polysaccharose on 
      diabetic mice induced by high-fat diet and streptozotocin.
PG  - 58-65
LID - S0378-8741(15)30258-0 [pii]
LID - 10.1016/j.jep.2015.12.002 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Anoectochilus roxburghii (Wall.) Lindl. 1832 is 
      an herbal medicine used to treat diabetes in China. Considering that 
      Anoectochilus roxburghii polysaccharose (ARP) is the main constituent of 
      Anoectochilus roxburghii, the present study is aimed to investigate the renal 
      protection of ARP and its possible mechanism in diabetic mice. MATERIALS AND 
      METHODS: Institute of Cancer Research (ICR) mice were induced to diabetes with 
      high-fat diet (HFD) and low-dose streptozotocin (STZ). ARP (100, 300 mg/kg) was 
      orally administrated to diabetic mice once a day for consecutive 15 days. The 
      fasting glucose level, expressions of key proteins of p38 MAP kinase cascade, 
      inflammatory factors, fibronectin (FN) and the activities of matrix 
      metalloproteinases (MMPs) were measured. Furthermore, the histological 
      examination of the separated kidneys was also carried out. RESULTS: Compared with 
      the diabetic mice, ARP administration induced a significant decrease in blood 
      glucose level and improved the body weight of diabetic mice. In addition, ARP 
      inhibited the expression of renal p38 MAP kinase cascade and its downstream 
      inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), monocyte 
      chemoattractant protein-1 (MCP-1), FN as well as MMP2/9. Moreover, the 
      histological examination showed an apparent reduction of mesangial matrix 
      deposition and damage of microvascular structure after ARP administration. 
      CONCLUSIONS: The protective effects of ARP on diabetic renal damage may be 
      attributed to the inhibition of p38 MAP kinase cascade and then attenuating the 
      inflammatory responses and high glucose-induced renal damage.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Li, Le
AU  - Li L
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian Province, PR China.
FAU - Li, Yu-Meng
AU  - Li YM
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian Province, PR China.
FAU - Liu, Zhen-Ling
AU  - Liu ZL
AD  - State Key Laboratory of Applied Organic Chemistry, Lanzhou 730000, PR China.
FAU - Zhang, Jian-Gang
AU  - Zhang JG
AD  - Institute of Pathology, Lanzhou University, Lanzhou 730000, PR China.
FAU - Liu, Qing
AU  - Liu Q
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian Province, PR China; 
      Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, 
      Fujian Province, PR China. Electronic address: liuq@hqu.edu.cn.
FAU - Yi, Li-Tao
AU  - Yi LT
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian Province, PR China; 
      Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, 
      Fujian Province, PR China. Electronic address: litaoyi@hqu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151203
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Blood Glucose)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 57-50-1 (Sucrose)
RN  - 5W494URQ81 (Streptozocin)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Blood Glucose/drug effects
MH  - Body Weight/drug effects
MH  - China
MH  - Diabetes Mellitus, Experimental/chemically induced/*drug therapy/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Drugs, Chinese Herbal/chemistry/pharmacology
MH  - Inflammation/drug therapy/metabolism
MH  - Kidney/*drug effects/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Orchidaceae/*chemistry
MH  - Streptozocin/pharmacology
MH  - Sucrose/*pharmacology
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
OTO - NOTNLM
OT  - Anoectochilus roxburghii
OT  - Diabetic renal damage
OT  - Inflammation
OT  - Polysaccharose
OT  - p38 MAP kinase
EDAT- 2015/12/15 06:00
MHDA- 2016/10/16 06:00
CRDT- 2015/12/15 06:00
PHST- 2015/07/28 00:00 [received]
PHST- 2015/10/25 00:00 [revised]
PHST- 2015/12/02 00:00 [accepted]
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2016/10/16 06:00 [medline]
AID - S0378-8741(15)30258-0 [pii]
AID - 10.1016/j.jep.2015.12.002 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2016 Feb 3;178:58-65. doi: 10.1016/j.jep.2015.12.002. Epub 2015 
      Dec 3.