PMID- 26656843 OWN - NLM STAT- MEDLINE DCOM- 20160919 LR - 20220331 IS - 1643-3750 (Electronic) IS - 1234-1010 (Print) IS - 1234-1010 (Linking) VI - 21 DP - 2015 Dec 14 TI - Low Concentration of BDNF in the Acute Phase of Ischemic Stroke as a Factor in Poor Prognosis in Terms of Functional Status of Patients. PG - 3900-5 AB - BACKGROUND According to recent studies, brain-derived neurotrophic factor (BDNF) probably plays a role in development of cerebral ischemia and can be significant for the prognosis of improved mobility after stroke. The aim of this prospective study was to evaluate the blood concentration of BDNF during the 1st day of first-ever ischemic stroke and find a potential association between BDNF concentration and the neurological status in the acute period, as well as between BDNF and the functional status in the sub-acute phase of stroke. MATERIAL AND METHODS The prospective study involved 87 patients aged 39-99 years (42 women, 45 men) with first-in-life complete ischemic stroke. All study subjects underwent analysis as follows: BDNF blood concentration and neurological status according to NIHSS on the 1st day of stroke, comorbidities, etiological type of ischemic stroke by ASCOD, and functional status on the 14th and 90th day after the onset according to mRankin scale. RESULTS Mean concentration of BDNF in the study group was 9.96 ng/mL+/-5.21, median 10.39 ng/mL. Patients aged 4 points by NIHSS (RR 1.14; 95% CI: 1.00-1.31; p=0.027) and the concentration of BDNF below the mean value (assessed on the 1st day of stroke) (RR 14.49; CI 4.60-45.45; p=0.000). CONCLUSIONS The neurological status and concentration of BDNF on the 1st day of ischemic stroke are independent prognostic factors in medium-term observation. Reduction in the concentration of BDNF in the acute phase of stroke is a factor for poor prognosis in terms of the functional status of patients on the 90th day after onset. FAU - Lasek-Bal, Anetta AU - Lasek-Bal A AD - Department of Neurology, Medical University of Silesia Hospital No. 7, Professor Leszek Giec Upper Silesian Medical Centre, Katowice, Poland. FAU - Jedrzejowska-Szypulka, Halina AU - Jedrzejowska-Szypulka H AD - Department of Physiology, School of Medicine, Medical University of Silesia in Katowice, Katowice, Poland. FAU - Rozycka, Jagoda AU - Rozycka J AD - Department of Neurology, Medical University of Silesia Hospital No. 7, Professor Leszek Giec Upper Silesian Medical Centre, Katowice, Poland. FAU - Bal, Wieslaw AU - Bal W AD - Department of Radiation Oncology and Chemotherapy, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland. FAU - Holecki, Michal AU - Holecki M AD - Department of Internal Medicine and Metabolic Diseases, Medical University of Silesia Hospital No. 7, Professor Leszek Giec Upper Silesian Medical Centre, Katowice, Poland. FAU - Dulawa, Jan AU - Dulawa J AD - Department of Internal Medicine and Metabolic Diseases, Medical University of Silesia Hospital No. 7, Professor Leszek Giec Upper Silesian Medical Centre, Katowice, Poland. FAU - Lewin-Kowalik, Joanna AU - Lewin-Kowalik J AD - Department of Physiology, School of Medicine, Medical University of Silesia in Katowice, Katowice, Poland. LA - eng PT - Journal Article DEP - 20151214 PL - United States TA - Med Sci Monit JT - Medical science monitor : international medical journal of experimental and clinical research JID - 9609063 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Acute Disease MH - Aged MH - Aged, 80 and over MH - Biomarkers/*blood MH - Brain Ischemia/*physiopathology MH - Brain-Derived Neurotrophic Factor/*blood MH - Female MH - Humans MH - Male MH - Middle Aged MH - Prognosis MH - Prospective Studies MH - Stroke/*physiopathology PMC - PMC4684138 EDAT- 2015/12/15 06:00 MHDA- 2016/09/20 06:00 PMCR- 2015/12/14 CRDT- 2015/12/15 06:00 PHST- 2015/12/15 06:00 [entrez] PHST- 2015/12/15 06:00 [pubmed] PHST- 2016/09/20 06:00 [medline] PHST- 2015/12/14 00:00 [pmc-release] AID - 895358 [pii] AID - 10.12659/msm.895358 [doi] PST - epublish SO - Med Sci Monit. 2015 Dec 14;21:3900-5. doi: 10.12659/msm.895358.