PMID- 26657145
OWN - NLM
STAT- MEDLINE
DCOM- 20161223
LR  - 20220129
IS  - 1440-1711 (Electronic)
IS  - 0818-9641 (Print)
IS  - 0818-9641 (Linking)
VI  - 94
IP  - 4
DP  - 2016 Apr
TI  - A central role for hepatic conventional dendritic cells in supporting Th2 
      responses during helminth infection.
PG  - 400-10
LID - 10.1038/icb.2015.114 [doi]
AB  - Dendritic cells (DCs) are the key initiators of T-helper (Th) 2 immune responses 
      against the parasitic helminth Schistosoma mansoni. Although the liver is one of 
      the main sites of antigen deposition during infection with this parasite, it is 
      not yet clear how distinct DC subtypes in this tissue respond to S. mansoni 
      antigens in vivo, or how the liver microenvironment might influence DC function 
      during establishment of the Th2 response. In this study, we show that hepatic DC 
      subsets undergo distinct activation processes in vivo following murine infection 
      with S. mansoni. Conventional DCs (cDCs) from schistosome-infected mice 
      upregulated expression of the costimulatory molecule CD40 and were capable of 
      priming naive CD4(+) T cells, whereas plasmacytoid DCs (pDCs) upregulated 
      expression of MHC class II, CD86 and CD40 but were unable to support the 
      expansion of either naive or effector/memory CD4(+) T cells. Importantly, in vivo 
      depletion of pDCs revealed that this subset was dispensable for either 
      maintenance or regulation of the hepatic Th2 effector response during acute S. 
      mansoni infection. Our data provides strong evidence that S. mansoni infection 
      favors the establishment of an immunogenic, rather than tolerogenic, liver 
      microenvironment that conditions cDCs to initiate and maintain Th2 immunity in 
      the context of ongoing antigen exposure.
FAU - Lundie, Rachel J
AU  - Lundie RJ
AD  - Institute of Immunology and Infection Research, Centre for Immunity, Infection 
      and Evolution, University of Edinburgh, Edinburgh, UK.
AD  - Centre for Biomedical Research, Burnet Institute, Melbourne, VIC, Australia.
FAU - Webb, Lauren M
AU  - Webb LM
AD  - Manchester Collaborative Centre for Inflammation Research, University of 
      Manchester, Manchester, UK.
FAU - Marley, Angela K
AU  - Marley AK
AD  - Institute of Immunology and Infection Research, Centre for Immunity, Infection 
      and Evolution, University of Edinburgh, Edinburgh, UK.
FAU - Phythian-Adams, Alexander T
AU  - Phythian-Adams AT
AD  - Manchester Collaborative Centre for Inflammation Research, University of 
      Manchester, Manchester, UK.
FAU - Cook, Peter C
AU  - Cook PC
AD  - Manchester Collaborative Centre for Inflammation Research, University of 
      Manchester, Manchester, UK.
FAU - Jackson-Jones, Lucy H
AU  - Jackson-Jones LH
AD  - Institute of Immunology and Infection Research, Centre for Immunity, Infection 
      and Evolution, University of Edinburgh, Edinburgh, UK.
FAU - Brown, Sheila
AU  - Brown S
AD  - Manchester Collaborative Centre for Inflammation Research, University of 
      Manchester, Manchester, UK.
FAU - Maizels, Rick M
AU  - Maizels RM
AD  - Institute of Immunology and Infection Research, Centre for Immunity, Infection 
      and Evolution, University of Edinburgh, Edinburgh, UK.
FAU - Boon, Louis
AU  - Boon L
AD  - EPIRUS Biopharmaceuticals, Utrecht, The Netherlands.
FAU - O'Keeffe, Meredith
AU  - O'Keeffe M
AD  - Centre for Biomedical Research, Burnet Institute, Melbourne, VIC, Australia.
AD  - Department of Biochemistry and Molecular Biology, Monash University, Melbourne, 
      VIC, Australia.
FAU - MacDonald, Andrew S
AU  - MacDonald AS
AD  - Manchester Collaborative Centre for Inflammation Research, University of 
      Manchester, Manchester, UK.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 106122/WT_/Wellcome Trust/United Kingdom
GR  - G0701437/MRC_/Medical Research Council/United Kingdom
GR  - N01AI30026/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151211
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
RN  - 0 (Antigens, Helminth)
SB  - IM
MH  - Animals
MH  - Antigens, Helminth/immunology
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology/parasitology
MH  - Liver/*immunology/parasitology
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Schistosoma mansoni/*immunology
MH  - Schistosomiasis mansoni/*immunology
MH  - Th2 Cells/*immunology
PMC - PMC4817239
MID - EMS66209
OID - NLM: EMS66209
COIS- The authors declare no conflict of interest.
EDAT- 2015/12/15 06:00
MHDA- 2016/12/24 06:00
PMCR- 2016/04/22
CRDT- 2015/12/15 06:00
PHST- 2015/09/04 00:00 [received]
PHST- 2015/11/24 00:00 [revised]
PHST- 2015/11/25 00:00 [accepted]
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2016/12/24 06:00 [medline]
PHST- 2016/04/22 00:00 [pmc-release]
AID - icb2015114 [pii]
AID - 10.1038/icb.2015.114 [doi]
PST - ppublish
SO  - Immunol Cell Biol. 2016 Apr;94(4):400-10. doi: 10.1038/icb.2015.114. Epub 2015 
      Dec 11.