PMID- 26658294 OWN - NLM STAT- MEDLINE DCOM- 20170216 LR - 20170216 IS - 1555-0273 (Electronic) IS - 1555-0265 (Linking) VI - 11 IP - 6 DP - 2016 Sep TI - Effect of Intensive Training on Mood With No Effect on Brain-Derived Neurotrophic Factor. PG - 824-830 AB - CONTEXT: Monitoring mood state is a useful tool for avoiding nonfunctional overreaching. Brain-derived neurotrophic factor (BDNF) is implicated in stress-related mood disorders. PURPOSE: To investigate the impact of intensified training-induced mood disturbance on plasma BDNF concentrations at rest and in response to exercise. METHODS: Eight cyclists performed 1 wk of normal (NT), 1 wk of intensified (INT), and 1 wk of recovery (REC) training. Fasted blood samples were collected before and after exercise on day 7 of each training week and analyzed for plasma BDNF and cortisol concentrations. A 24-item Profile of Mood State questionnaire was administered on day 7 of each training week, and global mood score (GMS) was calculated. RESULTS: Time-trial performance was impaired during INT (P = .01) and REC (P = .02) compared with NT. Basal plasma cortisol (NT = 153 +/- 16 ng/mL, INT = 130 +/- 11 ng/mL, REC = 150 +/- 14 ng/ml) and BDNF (NT = 484 +/- 122 pg/mL, INT = 488 +/- 122 pg/mL, REC = 383 +/- 56 pg/mL) concentrations were similar between training conditions. Likewise, similar exercise-induced increases in cortisol and BDNF concentrations were observed between training conditions. GMS was 32% greater during INT vs NT (P < .001). CONCLUSIONS: Consistent with a state of functional overreaching (FOR), impairments in performance and mood state with INT were restored after 1 wk of REC. These results support evidence for mood changes before plasma BDNF concentrations as a biochemical marker of FOR and that cortisol is not a useful marker for predicting FOR. FAU - Piacentini, Maria Francesca AU - Piacentini MF FAU - Witard, Oliver C AU - Witard OC FAU - Tonoli, Cajsa AU - Tonoli C FAU - Jackman, Sarah R AU - Jackman SR FAU - Turner, James E AU - Turner JE FAU - Kies, Arie K AU - Kies AK FAU - Jeukendrup, Asker E AU - Jeukendrup AE FAU - Tipton, Kevin D AU - Tipton KD FAU - Meeusen, Romain AU - Meeusen R LA - eng PT - Journal Article DEP - 20160824 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 RN - 0 (Brain-Derived Neurotrophic Factor) RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Adult MH - Affect/*physiology MH - Athletic Performance/*physiology MH - Bicycling/*physiology MH - Brain/physiology MH - Brain-Derived Neurotrophic Factor/*blood MH - Exercise/physiology/*psychology MH - Fatigue/metabolism/psychology MH - Humans MH - Hydrocortisone/blood MH - Physical Endurance MH - Physical Exertion/physiology MH - Surveys and Questionnaires MH - Young Adult OTO - NOTNLM OT - cortisol OT - functional overreaching OT - neurotrophins OT - psychological mood state OT - trained cyclists EDAT- 2015/12/15 06:00 MHDA- 2017/02/17 06:00 CRDT- 2015/12/15 06:00 PHST- 2015/12/15 06:00 [pubmed] PHST- 2017/02/17 06:00 [medline] PHST- 2015/12/15 06:00 [entrez] AID - 2015-0279 [pii] AID - 10.1123/ijspp.2015-0279 [doi] PST - ppublish SO - Int J Sports Physiol Perform. 2016 Sep;11(6):824-830. doi: 10.1123/ijspp.2015-0279. Epub 2016 Aug 24.