PMID- 26658588
OWN - NLM
STAT- MEDLINE
DCOM- 20161031
LR  - 20181113
IS  - 0971-5916 (Print)
IS  - 0971-5916 (Linking)
VI  - 142
IP  - 5
DP  - 2015 Nov
TI  - Ocular graft versus host disease in allogenic haematopoetic stem cell 
      transplantation in a tertiary care centre in India.
PG  - 543-8
LID - 10.4103/0971-5916.171280 [doi]
AB  - BACKGROUND & OBJECTIVES: This study was aimed to report the occurrence of ocular 
      graft versus host disease (oGVHD) in allogeneic haematopoietic stem cell 
      transplantation (allo-HSCT) patients in a tertiary care hospital setting. 
      METHODS: A cross-sectional study of ocular surface of allo-HSCT patients was 
      done. Slit lamp biomicroscopy, symptom score, tear meniscus height, fluorescein 
      tear break-up time, Schirmer's test I, ocular surface staining, dry eye severity, 
      ocular surface disease index score were done. Indications for allo-HSCT, human 
      leukocyte antigen (HLA) matching, GVHD risk factor, systemic manifestation and 
      treatment were also noted. RESULTS: GVHD occurred in 44.4 per cent of 54 
      allo-HSCT patients (mean age 26.7 +/- 12 yr) included in the study. GVHD risk 
      factors identified included female gender, relapse, older age of donor, 
      cytomagelo virus (CMV) reactivation, and multiparous female donors. oGVHD was 
      noted in 31.5 per cent with mean time to occurrence being 17.8 +/- 21.9 months 
      after the allo-HSCT and was observed in 89.5 per cent of chronic GVHD cases. 
      Acute GVHD (oral and dermatological) involvement showed a significant association 
      with GVHD in our patients (P< 0.001, 0R 23.0, CI 6.4-82.1). Chronic GVHD was 
      observed to be associated with the occurrence of oGVHD (dry eye) (P<0.001, OR = 
      24.0, CI 0.02 - 0.29). Of the 34 eyes with oGHVD, dry eye of level 3 severity was 
      seen in 16, level 2 in six, level 1 in 12 eyes. INTERPRETATION & CONCLUSIONS: 
      GVHD occurred in 44.4 per cent of the patients studied in the present study. 
      Acute and chronic GVHD showed a strong association with oGVHD. Dry eye disease 
      due to chronic oGVHD was observed in 17 (31.5%) of 54 allo-HSCT patient with 
      chronic oGVHD occurring in 17 (89.4%) of chronic GVHD cases in allo-HSCT 
      patients. Our study on oGVHD in post allo-HSCT patients in tertiary care centre 
      points towards the fact that ocular morbidity due to dry eye disease as a result 
      of oGVHD is a cause for concern in these patients.
FAU - Khan, Rehan
AU  - Khan R
FAU - Nair, Sridevi
AU  - Nair S
FAU - Seth, Tullika
AU  - Seth T
FAU - Mishra, Pravas
AU  - Mishra P
FAU - Mahapatra, Manoranjan
AU  - Mahapatra M
FAU - Agarwal, Tushar
AU  - Agarwal T
FAU - Tandon, Radhika
AU  - Tandon R
FAU - Vanathi, Murugesan
AU  - Vanathi M
AD  - Cornea & Ocular Surface, Cataract & Refractive Surgery Services, Dr Rajendra 
      Prasad Centre for Ophthalmic Sciences, New Delhi, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Res
JT  - The Indian journal of medical research
JID - 0374701
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Cross-Sectional Studies
MH  - *Dry Eye Syndromes
MH  - Female
MH  - *Graft vs Host Disease
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - India
MH  - Male
MH  - Middle Aged
MH  - Tertiary Care Centers
MH  - Young Adult
PMC - PMC4743340
COIS- Conflicts of Interest: None.
EDAT- 2015/12/15 06:00
MHDA- 2016/11/01 06:00
PMCR- 2015/11/01
CRDT- 2015/12/15 06:00
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2016/11/01 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - IndianJMedRes_2015_142_5_543_171280 [pii]
AID - IJMR-142-543 [pii]
AID - 10.4103/0971-5916.171280 [doi]
PST - ppublish
SO  - Indian J Med Res. 2015 Nov;142(5):543-8. doi: 10.4103/0971-5916.171280.