PMID- 26659264
OWN - NLM
STAT- MEDLINE
DCOM- 20160505
LR  - 20170719
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 879
DP  - 2016
TI  - Epigenetic Dysregulation in Virus-Associated Neoplasms.
PG  - 71-90
LID - 10.1007/978-3-319-24738-0_4 [doi]
AB  - The oncoproteins of human tumor viruses regularly interact with the cellular 
      epigenetic machinery. Such interactions alter the epigenome of the host cell and 
      reprogram its gene expression pattern. Altered levels or redistribution of 
      (cytosine-5)-DNA methyltransferases and changes in the cellular methylome were 
      observed in Kaposi sarcoma-associated herpesvirus (KSHV), hepatitis B virus 
      (HBV), hepatitis D virus (HDV), hepatitis C virus (HCV), and human papillomavirus 
      (HPV) associated neoplasms and cell lines. Methylation-mediated silencing of 
      cellular promoters was also noted in Merkel cell polyomavirus (MCPyV) positive 
      Merkel cell carcinomas, and, as discussed elsewhere, in EBV-associated 
      malignancies and adenovirus-induced rodent tumors as well. Promoter activation 
      also occurred, either associated with DNA hypomethylation or with the induction 
      of euchromatic histone modifications by viral oncoproteins. It is worthy to 
      notice that HCV infection induced large, hypomethylated blocks of cellular 
      chromatin, although the exact molecular mechanism remains to be elucidated. In 
      hepatoma cells expressing HBx, the oncoprotein encoded by the HBV genome, 
      demethylation of the repetitive satellite 2 sequences was observed, due to 
      downregulation of the de novo DNA methyltransferase DNMT3B. Tax and HBZ, the 
      oncoproteins of human T-cell lymphotropic virus type I (HTLV-I), can both 
      activate and silence distinct cellular promoters by interacting with cellular 
      enzymes involved in histone modification.
FAU - Minarovits, Janos
AU  - Minarovits J
AD  - Department of Oral Biology and Experimental Dental Research, Faculty of 
      Dentistry, University of Szeged, Tisza Lajos krt. 64, H-6720, Szeged, Hungary.
FAU - Demcsak, Anett
AU  - Demcsak A
AD  - Department of Oral Biology and Experimental Dental Research, Faculty of 
      Dentistry, University of Szeged, Tisza Lajos krt. 64, H-6720, Szeged, Hungary.
FAU - Banati, Ferenc
AU  - Banati F
AD  - RT-Europe Nonprofit Research Center, Mosonmagyarovar, Hungary.
FAU - Niller, Hans Helmut
AU  - Niller HH
AD  - Institute of Medical Microbiology and Hygiene, University of Regensburg, 
      Regensburg, Germany. hans-helmut.niller@klinik.uni-regensburg.de.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - *Cell Transformation, Viral
MH  - DNA Methylation
MH  - DNA, Neoplasm/genetics/*metabolism
MH  - *Epigenesis, Genetic
MH  - Humans
MH  - Neoplasm Proteins/genetics/*metabolism
MH  - Viral Proteins/genetics/*metabolism
MH  - Virus Diseases/genetics/*metabolism/pathology
MH  - Viruses/genetics/*metabolism
OTO - NOTNLM
OT  - CpG island shores
OT  - CpG shelves
OT  - Epigenetic reprogramming
OT  - Focal hypermethylation
OT  - Histone acetyltransferases
OT  - Relocation of chromatin binding proteins
OT  - Viral oncoproteins
EDAT- 2015/12/15 06:00
MHDA- 2016/05/06 06:00
CRDT- 2015/12/15 06:00
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2016/05/06 06:00 [medline]
AID - 10.1007/978-3-319-24738-0_4 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2016;879:71-90. doi: 10.1007/978-3-319-24738-0_4.