PMID- 26660110
OWN - NLM
STAT- MEDLINE
DCOM- 20171229
LR  - 20181113
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 53
IP  - 10
DP  - 2016 Dec
TI  - Manganese-Disrupted Interaction of Dopamine D1 and NMDAR in the Striatum to 
      Injury Learning and Memory Ability of Mice.
PG  - 6745-6758
AB  - Manganese (Mn) is widely regarded as a neurotoxic heavy metal that causes 
      learning and memory deficits. Recently, it has been proved that the striatum is 
      related to memory and learning ability. However, no previous study focused on the 
      effect of Mn-induced learning and memory deficits on the striatum. This study 
      aims to investigate the probable interaction of dopamine D1 receptor (DR1) and 
      N-methyl-D-aspartate receptor (NMDAR), two cognition-related receptors in the 
      striatum during Mn exposure. Mice are randomly divided into four groups, 
      including control group, 12.5 mg/kg MnCl(2) group, 25 mg/kg MnCl(2) group, and 
      50 mg/kg MnCl(2) group. The mice receive intraperitoneal injections of 0, 12.5, 
      25, and 50 mg/kg MnCl(2) once daily for 2 weeks. Then, learning and memory 
      ability, pathological changes, expression, and interaction of DR1 and NMDAR are 
      determined. It has been found that Mn disrupted spatial learning and memory 
      ability of mice by Morris water maze test and the passive avoidance test. 
      Pathological and ultrastructure were injured. Mn decreased the 
      immunohistochemical activities, protein levels, and messenger RNA (mRNA) 
      expression of DR1, NR1, and NR2A. Mn exposure inhibited interaction between DR1 
      and NMDAR in striatum by double immunofluorescent staining and 
      co-immunoprecipitation. In conclusion, our study illustrated that Mn caused 
      learning and memory dysfunction via injury of striatum and inhibition of 
      interaction between DR1 and NMDAR in striatum.
FAU - Song, Qifan
AU  - Song Q
AD  - Department of Environmental Health, School of Public Health, China Medical 
      University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, 
      People's Republic of China.
FAU - Deng, Yu
AU  - Deng Y
AD  - Department of Environmental Health, School of Public Health, China Medical 
      University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, 
      People's Republic of China. dengyu.cmu@163.com.
FAU - Yang, Xinxin
AU  - Yang X
AD  - Department of Environmental Health, School of Public Health, China Medical 
      University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, 
      People's Republic of China.
FAU - Bai, Ying
AU  - Bai Y
AD  - Department of Environmental Health, School of Public Health, China Medical 
      University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, 
      People's Republic of China.
FAU - Xu, Bin
AU  - Xu B
AD  - Department of Environmental Health, School of Public Health, China Medical 
      University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, 
      People's Republic of China.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of Environmental Health, School of Public Health, China Medical 
      University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, 
      People's Republic of China.
FAU - Zheng, Wenxue
AU  - Zheng W
AD  - Department of Environmental Health, School of Public Health, China Medical 
      University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, 
      People's Republic of China.
FAU - Wang, Can
AU  - Wang C
AD  - Department of Environmental Health, School of Public Health, China Medical 
      University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, 
      People's Republic of China.
FAU - Zhang, Meng
AU  - Zhang M
AD  - Department of Environmental Health, School of Public Health, China Medical 
      University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, 
      People's Republic of China.
FAU - Xu, Zhaofa
AU  - Xu Z
AD  - Department of Environmental Health, School of Public Health, China Medical 
      University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151211
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Receptors, Dopamine D1)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 42Z2K6ZL8P (Manganese)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Corpus Striatum/drug effects/*metabolism/ultrastructure
MH  - Escape Reaction/drug effects
MH  - Female
MH  - Immunohistochemistry
MH  - Male
MH  - Manganese/*toxicity
MH  - Memory/*drug effects
MH  - Mice
MH  - Protein Binding/drug effects
MH  - Receptors, Dopamine D1/*metabolism
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Spatial Learning/drug effects
OTO - NOTNLM
OT  - Dopamine D1 receptor
OT  - Learning and memory ability
OT  - Manganese
OT  - N-methyl-D-aspartate receptor
OT  - Striatum
EDAT- 2015/12/15 06:00
MHDA- 2017/12/30 06:00
CRDT- 2015/12/15 06:00
PHST- 2015/09/27 00:00 [received]
PHST- 2015/12/01 00:00 [accepted]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2017/12/30 06:00 [medline]
PHST- 2015/12/15 06:00 [entrez]
AID - 10.1007/s12035-015-9602-7 [pii]
AID - 10.1007/s12035-015-9602-7 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2016 Dec;53(10):6745-6758. doi: 10.1007/s12035-015-9602-7. Epub 
      2015 Dec 11.