PMID- 26660274
OWN - NLM
STAT- MEDLINE
DCOM- 20160622
LR  - 20160111
IS  - 1521-3765 (Electronic)
IS  - 0947-6539 (Linking)
VI  - 22
IP  - 3
DP  - 2016 Jan 18
TI  - Coordination Polymers Derived from Non-Steroidal Anti-Inflammatory Drugs for Cell 
      Imaging and Drug Delivery.
PG  - 988-98
LID - 10.1002/chem.201503706 [doi]
AB  - A new series of Mn(II) coordination polymers, namely, [Mn(L)(H2 O)2 ⋅2 Nap]infinity 
      (CP1), [Mn(L)(Ibu)2 (H2 O)2 ]infinity (CP2), [Mn(L)(Flr)2 (H2 O)2 ]infinity (CP3), 
      [Mn(L)(Ind)2 (H2 O)2 ⋅H2 O]infinity (CP4), [Mn2 (L)2 (mu-Flu)4 (H2 O)⋅L]infinity (CP5), 
      [Mn2 (L)2 (mu-Tol)4 (H2 O)2 ]infinity (CP6) and [Mn2 (L)2 (mu-Mef)4 (H2 O)2 ]infinity (CP7) 
      (Nap=naproxen, Ibu=ibuprofen, Flr=flurbiprofen, Ind=indometacin, Flu=flufenamic 
      acid, Tol=tolfenamic acid and Mef=mefenamic acid) derived from various 
      non-steroidal anti-inflammatory drugs (NSAIDs) and the organic linker 
      1,2-bis(4-pyridyl)ethylene (L) have been synthesized with the aim of being used 
      for cell imaging and drug delivery. Single-crystal X-ray diffraction (SXRD) 
      studies revealed that the NSAID molecules were part of the coordination polymeric 
      network either through coordination to the metal center (in the majority of the 
      cases) or through hydrogen bonding. Remarkably, all the Mn(II) coordination 
      polymers were found to be soluble in DMSO, thereby making them particularly 
      suitable for the desired biological applications. Two of the coordination 
      polymers (namely, CP1 and CP3) reported herein, were found to be photoluminescent 
      both in the solid as well as in the solution state. Subsequent experiments 
      (namely, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), and 
      PGE2 (prostaglandin E2 ) assays) established their biocompatibility and 
      anti-inflammatory response. In vitro studies by using a macrophage cell line 
      (i.e., RAW 264.7) revealed that both CP1 and CP3 were excellent cell imaging 
      agents. Finally, biodegradability studies under simulated physiological 
      conditions in phosphate-buffered saline (PBS) at pH 7.6 showed that slow and 
      sustained release of the corresponding NSAID was indeed possible from both CP1 
      and CP3.
CI  - (c) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Paul, Mithun
AU  - Paul M
AD  - Department of Organic Chemistry, Indian Association for the Cultivation of 
      Science (IACS), 2A and 2B, Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, 
      West Bengal, India), Fax.
FAU - Dastidar, Parthasarathi
AU  - Dastidar P
AD  - Department of Organic Chemistry, Indian Association for the Cultivation of 
      Science (IACS), 2A and 2B, Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, 
      West Bengal, India), Fax. ocpd@iacs.res.in.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151211
PL  - Germany
TA  - Chemistry
JT  - Chemistry (Weinheim an der Bergstrasse, Germany)
JID - 9513783
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Polymers)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/*chemistry
MH  - Diagnostic Imaging/*methods
MH  - Drug Delivery Systems/*methods
MH  - Hydrogen Bonding
MH  - Models, Molecular
MH  - Molecular Structure
MH  - Polymers/*chemistry
MH  - X-Ray Diffraction
OTO - NOTNLM
OT  - biocompatibility
OT  - cell imaging
OT  - coordination polymers
OT  - drug delivery
OT  - photoluminescence
EDAT- 2015/12/15 06:00
MHDA- 2016/06/23 06:00
CRDT- 2015/12/15 06:00
PHST- 2015/09/15 00:00 [received]
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2016/06/23 06:00 [medline]
AID - 10.1002/chem.201503706 [doi]
PST - ppublish
SO  - Chemistry. 2016 Jan 18;22(3):988-98. doi: 10.1002/chem.201503706. Epub 2015 Dec 
      11.