PMID- 26661115
OWN - NLM
STAT- MEDLINE
DCOM- 20160913
LR  - 20181113
IS  - 1865-7265 (Electronic)
IS  - 1865-7265 (Linking)
VI  - 8
IP  - 6
DP  - 2015 Dec
TI  - Genetic factors affect the etiology, clinical characteristics and outcome of 
      autoimmune hepatitis.
PG  - 360-6
LID - 10.1007/s12328-015-0620-9 [doi]
AB  - Autoimmune hepatitis (AIH) is characterized by chronic inflammation of the liver, 
      hypergammaglobulinemia, the presence of serum autoantibodies, histologic evidence 
      of interface hepatitis, and a favorable response to immunosuppressive treatment. 
      Although the etiology of AIH remains undefined, human leukocyte antigen (HLA) 
      class II alleles have been associated with disease onset for decades. AIH 
      resistance and severity are presumably linked to HLA alleles as well. Individuals 
      in different geographic regions of the world may have varying susceptibility 
      alleles that reflect indigenous triggering antigens. In this review, we describe 
      the influence of HLA alleles and gene polymorphisms on AIH, along with the 
      results of genome-wide association studies on this disease.
FAU - Umemura, Takeji
AU  - Umemura T
AUID- ORCID: 0000-0001-7985-919X
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu 
      University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan. 
      tumemura@shinshu-u.ac.jp.
FAU - Ota, Masao
AU  - Ota M
AD  - Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 
      Matsumoto, 390-8621, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151210
PL  - Japan
TA  - Clin J Gastroenterol
JT  - Clinical journal of gastroenterology
JID - 101477246
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - HLA Antigens/genetics
MH  - Hepatitis, Autoimmune/*genetics
MH  - Humans
MH  - Polymorphism, Genetic
OTO - NOTNLM
OT  - Autoimmune hepatitis
OT  - HLA
OT  - Primary biliary cirrhosis
EDAT- 2015/12/15 06:00
MHDA- 2016/09/14 06:00
CRDT- 2015/12/15 06:00
PHST- 2015/10/29 00:00 [received]
PHST- 2015/11/19 00:00 [accepted]
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2016/09/14 06:00 [medline]
AID - 10.1007/s12328-015-0620-9 [pii]
AID - 10.1007/s12328-015-0620-9 [doi]
PST - ppublish
SO  - Clin J Gastroenterol. 2015 Dec;8(6):360-6. doi: 10.1007/s12328-015-0620-9. Epub 
      2015 Dec 10.