PMID- 26662416
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20151215
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 4
DP  - 2015 Dec 8
TI  - Association between a functional single nucleotide polymorphism in the 
      brain-derived neurotrophic factor gene and risk of child asthma.
PG  - 16233-40
LID - 10.4238/2015.December.8.13 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) promotes synaptic remodeling and 
      modulates the function of other neurotransmitters. Allergic inflammation triggers 
      neuronal dysfunction and structural changes in the airways. Genetic polymorphisms 
      in functional regions of the BDNF gene have a plausible role in modulating the 
      risk of child asthma (CA). This study examined the potential association between 
      CA and three single nucleotide polymorphisms (SNPs) in BDNF (rs2030323, rs6265, 
      and rs16917204 in the promoter, exon 4, and 3'-untranslated regions, 
      respectively). The study was conducted in 350 children with asthma and 356 
      healthy controls. The genotype and allele frequencies and difference between 
      groups were analyzed using HaploView 4.0 and SPSS 20.0 software platforms. The 
      analysis revealed a strong association between the rs6265 genotype distribution 
      and CA. The frequency of the G allele was significantly higher in CA patients 
      than in healthy controls (P = 0.0007, odds ratio = 1.323, 95% confidence interval 
      = 1.073-1.632). Strong linkage disequilibrium was observed between rs16917204 and 
      rs6265. A significantly higher number of G-G haplotypes were observed in CA 
      patients than in controls (P = 0.024 after Bonferroni correction), while the G-A 
      haplotypes were more significant in controls (P = 0.013 after Bonferroni 
      correction). This suggested that BDNF gene polymorphisms confer susceptibility to 
      CA, and also support the notion that BDNF dysfunction is involved in the 
      pathophysiological process of CA.
FAU - Wang, J Y
AU  - Wang JY
AD  - The Third Ward, Xi'an Children's Hospital, Shaanxi Province People's Hospital, 
      Xi'an, China.
FAU - Wang, A L
AU  - Wang AL
AD  - The Department of Pediatrics, Chinese Medicine Hospital, Baoji, Shanxi Province, 
      China.
FAU - Han, W
AU  - Han W
AD  - The Third Ward, Xi'an Children's Hospital, Shaanxi Province People's Hospital, 
      Xi'an, China.
FAU - Mu, Z L
AU  - Mu ZL
AD  - The Third Ward, Xi'an Children's Hospital, Shaanxi Province People's Hospital, 
      Xi'an, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151208
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Alleles
MH  - Asthma/epidemiology/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - Epistasis, Genetic
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Risk
EDAT- 2015/12/15 06:00
MHDA- 2016/09/16 06:00
CRDT- 2015/12/15 06:00
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
AID - gmr6935 [pii]
AID - 10.4238/2015.December.8.13 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Dec 8;14(4):16233-40. doi: 10.4238/2015.December.8.13.