PMID- 26662461
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20230921
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Print)
IS  - 1050-9631 (Linking)
VI  - 26
IP  - 6
DP  - 2016 Jun
TI  - The requirement of BDNF for hippocampal synaptic plasticity is 
      experience-dependent.
PG  - 739-51
LID - 10.1002/hipo.22555 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) supports neuronal survival, growth, and 
      differentiation and has been implicated in forms of hippocampus-dependent 
      learning. In vitro, a specific role in hippocampal synaptic plasticity has been 
      described, although not all experience-dependent forms of synaptic plasticity 
      critically depend on BDNF. Synaptic plasticity is likely to enable long-term 
      synaptic information storage and memory, and the induction of persistent (>24 h) 
      forms, such as long-term potentiation (LTP) and long-term depression (LTD) is 
      tightly associated with learning specific aspects of a spatial representation. 
      Whether BDNF is required for persistent (>24 h) forms of LTP and LTD, and how it 
      contributes to synaptic plasticity in the freely behaving rodent has never been 
      explored. We examined LTP, LTD, and related forms of learning in the CA1 region 
      of freely dependent mice that have a partial knockdown of BDNF (BDNF(+/-) ). We 
      show that whereas early-LTD (<90min) requires BDNF, short-term depression (<45 
      min) does not. Furthermore, BDNF is required for LTP that is induced by mild, but 
      not strong short afferent stimulation protocols. Object-place learning triggers 
      LTD in the CA1 region of mice. We observed that object-place memory was impaired 
      and the object-place exploration failed to induce LTD in BDNF(+/-) mice. 
      Furthermore, spatial reference memory, that is believed to be enabled by LTP, was 
      also impaired. Taken together, these data indicate that BDNF is required for 
      specific, but not all, forms of hippocampal-dependent information storage and 
      memory. Thus, very robust forms of synaptic plasticity may circumvent the need 
      for BDNF, rather it may play a specific role in the optimization of weaker forms 
      of plasticity. The finding that both learning-facilitated LTD and spatial 
      reference memory are both impaired in BDNF(+/-) mice, suggests moreover, that it 
      is critically required for the physiological encoding of hippocampus-dependent 
      memory. (c) 2015 The Authors Hippocampus Published by Wiley Periodicals, Inc.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Aarse, Janna
AU  - Aarse J
AD  - Department of Neurophysiology, Medical Faculty.
AD  - International Graduate School of Neuroscience.
FAU - Herlitze, Stefan
AU  - Herlitze S
AD  - Faculty of Biology and Biotechnology, Department of Zoology and Neurobiology Ruhr 
      University, Bochum, 44780 Bochum, Germany.
FAU - Manahan-Vaughan, Denise
AU  - Manahan-Vaughan D
AD  - Department of Neurophysiology, Medical Faculty.
AD  - International Graduate School of Neuroscience.
LA  - eng
PT  - Journal Article
DEP - 20160119
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*deficiency/genetics
MH  - CA1 Region, Hippocampal/*metabolism
MH  - Electrodes, Implanted
MH  - Exploratory Behavior/physiology
MH  - Learning/*physiology
MH  - Long-Term Potentiation/*physiology
MH  - Long-Term Synaptic Depression/*physiology
MH  - Male
MH  - Memory Disorders/metabolism
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Recognition, Psychology/physiology
MH  - Space Perception/physiology
MH  - Spatial Memory/*physiology
PMC - PMC5066736
OTO - NOTNLM
OT  - CA1
OT  - LTD
OT  - LTP
OT  - enrichment
OT  - object recognition
EDAT- 2015/12/15 06:00
MHDA- 2018/01/09 06:00
PMCR- 2016/10/17
CRDT- 2015/12/15 06:00
PHST- 2015/12/03 00:00 [accepted]
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
PHST- 2016/10/17 00:00 [pmc-release]
AID - HIPO22555 [pii]
AID - 10.1002/hipo.22555 [doi]
PST - ppublish
SO  - Hippocampus. 2016 Jun;26(6):739-51. doi: 10.1002/hipo.22555. Epub 2016 Jan 19.