PMID- 26663065
OWN - NLM
STAT- MEDLINE
DCOM- 20160523
LR  - 20151215
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 32
IP  - 6
DP  - 2015 Dec
TI  - [Effect of mitochondrial DNA 5178 C/A polymorphism on risks for type 2 diabetes 
      mellitus and its complications].
PG  - 855-60
LID - 10.3760/cma.j.issn.1003-9406.2015.06.023 [doi]
AB  - OBJECTIVE: To explore the role of mitochondrial DNA 5178 C/A (Mt5178) 
      polymorphism of NADH-dehydrogenase subunit 2 (ND2) gene in type-2 diabetes 
      mellitus (T2DM) among ethnic Han Chinese through a case-control study. METHODS: 
      The Mt5178C/A polymorphism was determined by sequencing 1103 T2DM patients and 
      791 healthy controls. Logistic regression analysis was conducted to estimate odds 
      ratios (OR) and 95% confidence intervals (CI). To confirm the results, a 
      meta-analysis was conducted based on published literature on the association of 
      Mt5178 variant with T2DM. RESULTS: No significant association was found between 
      the Mt5178C/A variant and T2DM either by our study or the meta-analysis which 
      included eight published studies. Nevertheless, it was found that the T2DM 
      patients with 5178C genotype were at a higher risk for nephropathy complication 
      (OR=1.49, 95%CI: 1.005-2.197, P<0.05) and at significantly lower risk for 
      hypertension complication (OR=0.744, 95%CI: 0.556-0.996, P<0.05) compared with 
      those carrying a 5178A genotype. CONCLUSION: No association was found between the 
      Mt5178C/A polymorphism of mitochondrial ND2 gene with the increased risk of T2DM. 
      However, the polymorphism may affect the development of nephropathy and 
      hypertension complications among T2DM patients.
FAU - Yang, Xunjun
AU  - Yang X
AD  - Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical 
      University, Wenzhou, Zhejiang 325000, P.R. China. jxlu313@163.com.
FAU - Zhang, Yuning
AU  - Zhang Y
FAU - Ma, Yin
AU  - Ma Y
FAU - Zhao, Qiongya
AU  - Zhao Q
FAU - Lyu, Jianxin
AU  - Lyu J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (DNA, Mitochondrial)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - DNA, Mitochondrial/chemistry/*genetics
MH  - Diabetes Complications/blood/*genetics
MH  - Diabetes Mellitus, Type 2/blood/complications/*genetics
MH  - Diabetic Nephropathies/blood/genetics
MH  - Fasting/blood
MH  - Female
MH  - Humans
MH  - Hypertension/blood/complications/genetics
MH  - Male
MH  - Meta-Analysis as Topic
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Sequence Analysis, DNA
MH  - Triglycerides/blood
EDAT- 2015/12/15 06:00
MHDA- 2016/05/24 06:00
CRDT- 2015/12/15 06:00
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2016/05/24 06:00 [medline]
AID - 940632181 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2015.06.023 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015 Dec;32(6):855-60. doi: 
      10.3760/cma.j.issn.1003-9406.2015.06.023.