PMID- 26663222
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20211204
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Print)
IS  - 1050-9631 (Linking)
VI  - 26
IP  - 6
DP  - 2016 Jun
TI  - Target-selectivity of parvalbumin-positive interneurons in layer II of medial 
      entorhinal cortex in normal and epileptic animals.
PG  - 779-93
LID - 10.1002/hipo.22559 [doi]
AB  - The medial entorhinal cortex layer II (MEClayerII ) is a brain region critical 
      for spatial navigation and memory, and it also demonstrates a number of changes 
      in patients with, and animal models of, temporal lobe epilepsy (TLE). Prior 
      studies of GABAergic microcircuitry in MEClayerII revealed that 
      cholecystokinin-containing basket cells (CCKBCs) select their targets on the 
      basis of the long-range projection pattern of the postsynaptic principal cell. 
      Specifically, CCKBCs largely avoid reelin-containing principal cells that form 
      the perforant path to the ipsilateral dentate gyrus and preferentially innervate 
      non-perforant path forming calbindin-containing principal cells. We investigated 
      whether parvalbumin containing basket cells (PVBCs), the other major perisomatic 
      targeting GABAergic cell population, demonstrate similar postsynaptic target 
      selectivity as well. In addition, we tested the hypothesis that the functional or 
      anatomic arrangement of circuit selectivity is disrupted in MEClayerII in chronic 
      TLE, using the repeated low-dose kainate model in rats. In control animals, we 
      found that PVBCs innervated both principal cell populations, but also had 
      significant selectivity for calbindin-containing principal cells in MEClayerII . 
      However, the magnitude of this preference was smaller than for CCKBCs. In 
      addition, axonal tracing and paired recordings showed that individual PVBCs were 
      capable of contacting both calbindin and reelin-containing principal cells. In 
      chronically epileptic animals, we found that the intrinsic properties of the two 
      principal cell populations, the GABAergic perisomatic bouton numbers, and 
      selectivity of the CCKBCs and PVBCs remained remarkably constant in MEClayerII . 
      However, miniature IPSC frequency was decreased in epilepsy, and paired 
      recordings revealed the presence of direct excitatory connections between 
      principal cells in the MEClayerII in epilepsy, which is unusual in normal adult 
      MEClayerII . Taken together, these findings advance our knowledge about the 
      organization of perisomatic inhibition both in control and in epileptic animals. 
      (c) 2015 Wiley Periodicals, Inc.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Armstrong, Caren
AU  - Armstrong C
AD  - Irvine Department of Anatomy & Neurobiology, University of California, Irvine, 
      California.
FAU - Wang, Jessica
AU  - Wang J
AD  - Irvine Department of Anatomy & Neurobiology, University of California, Irvine, 
      California.
FAU - Yeun Lee, Soo
AU  - Yeun Lee S
AD  - Irvine Department of Anatomy & Neurobiology, University of California, Irvine, 
      California.
FAU - Broderick, John
AU  - Broderick J
AD  - Irvine Department of Anatomy & Neurobiology, University of California, Irvine, 
      California.
FAU - Bezaire, Marianne J
AU  - Bezaire MJ
AD  - Irvine Department of Anatomy & Neurobiology, University of California, Irvine, 
      California.
FAU - Lee, Sang-Hun
AU  - Lee SH
AD  - Irvine Department of Anatomy & Neurobiology, University of California, Irvine, 
      California.
FAU - Soltesz, Ivan
AU  - Soltesz I
AD  - Irvine Department of Anatomy & Neurobiology, University of California, Irvine, 
      California.
AD  - Department of Neurosurgery, Stanford University, Palo Alto, CA.
LA  - eng
GR  - F32 NS090753/NS/NINDS NIH HHS/United States
GR  - P30 CA062203/CA/NCI NIH HHS/United States
GR  - R01 NS074432/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20160129
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - 0 (Calbindins)
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Parvalbumins)
RN  - 0 (Reelin Protein)
RN  - 0 (Reln protein, rat)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 9011-97-6 (Cholecystokinin)
RN  - EC 3.4.21.- (Serine Endopeptidases)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Animals
MH  - Calbindins/metabolism
MH  - Cell Adhesion Molecules, Neuronal/metabolism
MH  - Cholecystokinin/metabolism
MH  - Disease Models, Animal
MH  - Entorhinal Cortex/*cytology/metabolism/pathology
MH  - Epilepsy, Temporal Lobe/metabolism/*pathology
MH  - Extracellular Matrix Proteins/metabolism
MH  - Female
MH  - Inhibitory Postsynaptic Potentials
MH  - Interneurons/*cytology/metabolism/pathology
MH  - Kainic Acid
MH  - Male
MH  - Miniature Postsynaptic Potentials
MH  - Nerve Tissue Proteins/metabolism
MH  - Neural Pathways/cytology/metabolism/pathology
MH  - Parvalbumins/*metabolism
MH  - Presynaptic Terminals/metabolism/pathology
MH  - Rats, Wistar
MH  - Reelin Protein
MH  - Serine Endopeptidases/metabolism
MH  - Tissue Culture Techniques
MH  - gamma-Aminobutyric Acid/metabolism
PMC - PMC4866882
MID - NIHMS745016
OTO - NOTNLM
OT  - MEC
OT  - basket cell
OT  - calbindin
OT  - perisomatic inhibition
OT  - reelin
EDAT- 2015/12/15 06:00
MHDA- 2018/01/09 06:00
PMCR- 2017/06/01
CRDT- 2015/12/15 06:00
PHST- 2015/12/10 00:00 [accepted]
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - 10.1002/hipo.22559 [doi]
PST - ppublish
SO  - Hippocampus. 2016 Jun;26(6):779-93. doi: 10.1002/hipo.22559. Epub 2016 Jan 29.