PMID- 26663759
OWN - NLM
STAT- MEDLINE
DCOM- 20180130
LR  - 20180130
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 8
IP  - 6
DP  - 2016 Nov
TI  - Demographic and clinical characteristics of patients with type 1 diabetes 
      mellitus: A multicenter registry study in Guangdong, China.
PG  - 847-853
LID - 10.1111/1753-0407.12366 [doi]
AB  - BACKGROUND: A lack of demographic and clinical data hinders efforts of health 
      care providers in China to support patients with type 1 diabetes mellitus (T1D). 
      Therefore, the aim of the present retrospective study was to provide an overview 
      of the demographic and clinical characteristics of Chinese patients with T1D. 
      METHODS: Hospital medical records of patients with T1D (diagnosed between January 
      2000 and December 2011) in 105 secondary and tertiary hospitals across Guangdong 
      province were reviewed. Data were collected on patient age at diagnosis, 
      presentations at onset, physical examination, and diabetes management. RESULTS: 
      In all, 3173 patients diagnosed with T1D between January 2000 and December 2011 
      were included in the study (46.2% female). The median age at diagnosis was 
      27.5 years (interquartile range [IQR] 18.0-38.0) years and the median body mass 
      index (BMI) at onset was 19.6 kg/m(2) (IQR 17.4-21.8 kg/m(2) ). Among adult 
      patients, 0.9% were obese, 6.6% were overweight, 62.3% were normal weight, and 
      30.3 % were underweight. The prevalence of diabetic ketoacidosis (DKA) at onset 
      was 50.1%. The proportion of patients with retinopathy, nephropathy, and 
      neuropathy was 8.1%, 20.7 %, and 11.1%, respectively. CONCLUSION: The adult-onset 
      form of T1D is not rare in China. The registry participants were characterized by 
      older age at onset, lower BMI, and a higher prevalence of DKA at onset compared 
      with those in regions with a high incidence of T1D, such as northern Europe. 
      These findings contribute to a better understanding of the heterogeneity of T1D 
      in different populations and so will help healthcare providers to develop 
      management models that are more suitable for these patients.
CI  - (c) 2015 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John 
      Wiley & Sons Australia, Ltd.
FAU - Yang, Daizhi
AU  - Yang D
AD  - Department of Endocrinology & Metabolic Disease, The 3rd Affiliated Hospital of 
      Sun Yat-sen University.
AD  - Guangdong Diabetes Center, Guangzhou.
FAU - Deng, Hongrong
AU  - Deng H
AD  - Department of Endocrinology & Metabolic Disease, The 3rd Affiliated Hospital of 
      Sun Yat-sen University.
AD  - Guangdong Diabetes Center, Guangzhou.
FAU - Luo, Guochun
AU  - Luo G
AD  - The 1st Affiliated Hospital of Shenzhen University, Shenzen.
FAU - Wu, Ge
AU  - Wu G
AD  - Affiliated Hospital of Guangdong Medical College, Zhanjiang.
FAU - Lin, Shaoda
AU  - Lin S
AD  - The 1st Affiliated Hospital of Shantou University Medical College, Shantou.
FAU - Yuan, Lin
AU  - Yuan L
AD  - Zhuhai People's Hospital, Zhuhai.
FAU - Xv, Meilun
AU  - Xv M
AD  - Huizhou Municipal Central Hosptial, Huizhou.
FAU - Li, Shaoqing
AU  - Li S
AD  - Qingyuan People's Hospital, Qingyuan.
FAU - Zhang, Xiuwei
AU  - Zhang X
AD  - Dongguan People's Hospital, Dongguan.
FAU - Wu, Jianneng
AU  - Wu J
AD  - Yue Bei People's Hospital, Shaoguan.
FAU - Lang, Jiangming
AU  - Lang J
AD  - Foshan Hospital of Traditional Chinese Medicine, Foshan.
FAU - Liang, Ganxiong
AU  - Liang G
AD  - Zhongshan People's Hospital, Zhongshan.
FAU - Lin, Jiancai
AU  - Lin J
AD  - Jiangmen Central Hospital, Jiangmen.
FAU - Chen, Dingyu
AU  - Chen D
AD  - Guangzhou 1st Municipal People's Hospital, Guangzhou.
FAU - Li, Lu
AU  - Li L
AD  - Shenzhen People's Hospital, Shenzhen.
FAU - Fang, Yishan
AU  - Fang Y
AD  - Jieyang People's Hospital, Jieyang.
FAU - Wu, Yongxin
AU  - Wu Y
AD  - Meizhou People's Hospital, Meizhou.
FAU - Ou, Wenxin
AU  - Ou W
AD  - Maoming People's Hospital, Maoming, China.
FAU - Li, Jin
AU  - Li J
AD  - Department of Endocrinology & Metabolic Disease, The 3rd Affiliated Hospital of 
      Sun Yat-sen University.
AD  - Guangdong Diabetes Center, Guangzhou.
FAU - Weng, Jianping
AU  - Weng J
AD  - Department of Endocrinology & Metabolic Disease, The 3rd Affiliated Hospital of 
      Sun Yat-sen University.
AD  - Guangdong Diabetes Center, Guangzhou.
FAU - Yan, Jinhua
AU  - Yan J
AD  - Department of Endocrinology & Metabolic Disease, The 3rd Affiliated Hospital of 
      Sun Yat-sen University. yanjh79@163.com.
AD  - Guangdong Diabetes Center, Guangzhou. yanjh79@163.com.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20160306
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - *Demography
MH  - Diabetes Mellitus, Type 1/*epidemiology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - *Registries
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - 1型糖尿病
OT  - China
OT  - epidemiology
OT  - type 1 diabetes mellitus
OT  - 中国
OT  - 流行病学
EDAT- 2015/12/15 06:00
MHDA- 2018/01/31 06:00
CRDT- 2015/12/15 06:00
PHST- 2015/05/21 00:00 [received]
PHST- 2015/10/27 00:00 [revised]
PHST- 2015/12/06 00:00 [accepted]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2018/01/31 06:00 [medline]
PHST- 2015/12/15 06:00 [entrez]
AID - 10.1111/1753-0407.12366 [doi]
PST - ppublish
SO  - J Diabetes. 2016 Nov;8(6):847-853. doi: 10.1111/1753-0407.12366. Epub 2016 Mar 6.