PMID- 26663917 OWN - NLM STAT- MEDLINE DCOM- 20160920 LR - 20181113 IS - 0008-5286 (Print) IS - 0008-5286 (Linking) VI - 56 IP - 12 DP - 2015 Dec TI - Intraoperative acridine orange photodynamic therapy and cribriform electron-beam irradiation for canine intranasal tumors: A pilot study. PG - 1232-8 AB - Untreated canine intranasal tumors carry a poor prognosis. We retrospectively evaluated the efficacy of marginal tumor resection in combination with intraoperative acridine orange (AO) photodynamic therapy (PDT) and 1 fraction of 5 Gy megavoltage irradiation for canine intranasal malignant tumors. When cribriform plate invasion or turbinate destruction around the cribriform plate was present, an additional fraction of 20 Gy was delivered with an electron beam during surgery. The study included 6 dogs, 2 of which were classified as stage I, 1 as stage II, and 3 as stage IV. The median local disease-free survival time and overall survival after the treatment were 8.5 and 13 months, respectively. Recurrence was noted in 2 of the 6 dogs after 4 and 7 months. Adverse events were mild (subcutaneous emphysema in 1 case, and rhinitis in 3 cases). Combination AO therapy may increase the tumor control time of dogs with marginally resectable intranasal malignant tumors. FAU - Maruo, Takuya AU - Maruo T AD - Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama). FAU - Nagata, Koichi AU - Nagata K AD - Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama). FAU - Fukuyama, Yasuhiro AU - Fukuyama Y AD - Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama). FAU - Nemoto, Yuki AU - Nemoto Y AD - Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama). FAU - Kawarai, Shinpei AU - Kawarai S AD - Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama). FAU - Fujita, Yukihiro AU - Fujita Y AD - Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama). FAU - Nakayama, Tomohiro AU - Nakayama T AD - Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama). LA - eng PT - Clinical Trial PT - Journal Article PL - Canada TA - Can Vet J JT - The Canadian veterinary journal = La revue veterinaire canadienne JID - 0004653 RN - 0 (Fluorescent Dyes) RN - 0 (Photosensitizing Agents) RN - F30N4O6XVV (Acridine Orange) SB - IM MH - Acridine Orange/*therapeutic use MH - Animals MH - Dog Diseases/*drug therapy/radiotherapy/surgery MH - Dogs MH - Female MH - Fluorescent Dyes/*therapeutic use MH - Intraoperative Care/veterinary MH - Male MH - Nose Neoplasms/drug therapy/radiotherapy/surgery/*veterinary MH - Photochemotherapy/*veterinary MH - Photosensitizing Agents/therapeutic use MH - Pilot Projects MH - Retrospective Studies PMC - PMC4668819 EDAT- 2015/12/15 06:00 MHDA- 2016/09/22 06:00 PMCR- 2016/06/01 CRDT- 2015/12/15 06:00 PHST- 2015/12/15 06:00 [entrez] PHST- 2015/12/15 06:00 [pubmed] PHST- 2016/09/22 06:00 [medline] PHST- 2016/06/01 00:00 [pmc-release] AID - cvj_12_1232 [pii] PST - ppublish SO - Can Vet J. 2015 Dec;56(12):1232-8.