PMID- 26663920
OWN - NLM
STAT- MEDLINE
DCOM- 20160920
LR  - 20181113
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 56
IP  - 12
DP  - 2015 Dec
TI  - Evaluation of plasma inflammatory cytokine concentrations in racing sled dogs.
PG  - 1252-6
AB  - In human athletes significant changes in cytokine concentrations secondary to 
      exercise have been observed. This prospective study evaluated the effect of a 
      multi-day stage sled dog race on plasma concentrations of monocyte 
      chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha), 
      interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), and 
      interleukin-10 (IL-10). Samples from 20 dogs were harvested prior to and on days 
      2 and 8 of an 8-day race. Exercise resulted in significantly decreased TNF-alpha and 
      IL-8 as well as increases of MCP-1, IL-6, and IL-10 concentrations (P-value 
      between 0.01 and < 0.0001 for all parameters). The proportion of values for IL-2 
      that were below the detection limit increased from 40% on day 0 to 75% on day 2 
      and decreased on day 8 to 40% (P = 0.04). Racing sled dogs show 
      cytokine-concentration changes that are different from those in humans.
FAU - von Pfeil, Dirsko J F
AU  - von Pfeil DJ
AD  - Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, 
      Washington, District of Columbia 20016, USA (von Pfeil); Department of Small 
      Animal Clinical Sciences, College of Veterinary Medicine, Michigan State 
      University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of 
      Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, 
      Wakshlag), Department of Population Medicine (Mann), College of Veterinary 
      Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, 
      Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, 
      Colorado, USA (Griffitts).
FAU - Cummings, Bethany P
AU  - Cummings BP
AD  - Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, 
      Washington, District of Columbia 20016, USA (von Pfeil); Department of Small 
      Animal Clinical Sciences, College of Veterinary Medicine, Michigan State 
      University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of 
      Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, 
      Wakshlag), Department of Population Medicine (Mann), College of Veterinary 
      Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, 
      Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, 
      Colorado, USA (Griffitts).
FAU - Loftus, John P
AU  - Loftus JP
AD  - Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, 
      Washington, District of Columbia 20016, USA (von Pfeil); Department of Small 
      Animal Clinical Sciences, College of Veterinary Medicine, Michigan State 
      University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of 
      Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, 
      Wakshlag), Department of Population Medicine (Mann), College of Veterinary 
      Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, 
      Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, 
      Colorado, USA (Griffitts).
FAU - Levine, Corri B
AU  - Levine CB
AD  - Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, 
      Washington, District of Columbia 20016, USA (von Pfeil); Department of Small 
      Animal Clinical Sciences, College of Veterinary Medicine, Michigan State 
      University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of 
      Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, 
      Wakshlag), Department of Population Medicine (Mann), College of Veterinary 
      Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, 
      Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, 
      Colorado, USA (Griffitts).
FAU - Mann, Sabine
AU  - Mann S
AD  - Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, 
      Washington, District of Columbia 20016, USA (von Pfeil); Department of Small 
      Animal Clinical Sciences, College of Veterinary Medicine, Michigan State 
      University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of 
      Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, 
      Wakshlag), Department of Population Medicine (Mann), College of Veterinary 
      Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, 
      Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, 
      Colorado, USA (Griffitts).
FAU - Downey, Robert L
AU  - Downey RL
AD  - Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, 
      Washington, District of Columbia 20016, USA (von Pfeil); Department of Small 
      Animal Clinical Sciences, College of Veterinary Medicine, Michigan State 
      University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of 
      Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, 
      Wakshlag), Department of Population Medicine (Mann), College of Veterinary 
      Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, 
      Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, 
      Colorado, USA (Griffitts).
FAU - Griffitts, Caroline
AU  - Griffitts C
AD  - Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, 
      Washington, District of Columbia 20016, USA (von Pfeil); Department of Small 
      Animal Clinical Sciences, College of Veterinary Medicine, Michigan State 
      University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of 
      Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, 
      Wakshlag), Department of Population Medicine (Mann), College of Veterinary 
      Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, 
      Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, 
      Colorado, USA (Griffitts).
FAU - Wakshlag, Joseph J
AU  - Wakshlag JJ
AD  - Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, 
      Washington, District of Columbia 20016, USA (von Pfeil); Department of Small 
      Animal Clinical Sciences, College of Veterinary Medicine, Michigan State 
      University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of 
      Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, 
      Wakshlag), Department of Population Medicine (Mann), College of Veterinary 
      Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, 
      Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, 
      Colorado, USA (Griffitts).
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Cytokines/*blood/metabolism
MH  - Dogs/blood/*immunology
MH  - Female
MH  - Gene Expression Regulation/physiology
MH  - Male
MH  - *Sports
PMC - PMC4668826
EDAT- 2015/12/15 06:00
MHDA- 2016/09/22 06:00
PMCR- 2016/06/01
CRDT- 2015/12/15 06:00
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2016/09/22 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - cvj_12_1252 [pii]
PST - ppublish
SO  - Can Vet J. 2015 Dec;56(12):1252-6.